微环境pH值对创面愈合的作用研究进展

Advances in the effects of pH value of micro-environment on wound healing

创面愈合是指致伤因子造成组织缺失后，局部组织通过再生、修复、重建进行修补的过程，按愈合时间将创面分为急性创面和慢性创面。影响创面愈合的因素很多，包括年龄、营养、烟酒、潜在或伴发疾病、心理状态等全身因素，异物、感染、血供、湿度、压力、摩擦力、剪切力等局部因素。

Wound healing is a complex regeneration process, which is affected by lots of endogenous and exogenous factors. Researches have confirmed that acid environment could prevent wound infection and accelerate wound healing by inhibiting bacteria proliferation, promoting oxygen release, affecting keratinocyte proliferation and migration, etc. In this article, we review the literature to identify the potential relationship between the pH value of wound micro-environment and the progress of wound healing, and summarize the clinical application of variation of pH value of micro-environment in wound healing, thereby to provide new treatment strategy for wound healing.