急性冠状动脉综合征患者血清高敏C-反应蛋白和γ-谷氨酰转移酶水平变化

Changes in the levels of serum high sensitive C reaction protein and γ-glutamyl transpeptidase in patients with acute coronary syndrome

目的探讨急性冠状动脉综合征(ACS)患者血清高敏C-反应蛋白(hs-CRP)和γ-谷氨酰转移酶(γ-GGT)水平的变化。方法选取2013年10月至2014年12月在宜宾市第一人民医院住院治疗的ACS患者80例,其中不稳定型心绞痛(UA)患者41例(UA组),急性心肌梗死(AMI)患者39例(AMI组)。另选择同期体检健康者40例作为对照组。对3组受试者血清hs-CRP和γ-GGT水平进行比较。结果 UA组、AMI组患者血清hs-CRP和γ-GGT水平显著高于对照组(P<0.01);AMI组患者血清hs-CRP和γ-GGT水平显著高于UA组(P<0.05)。UA组和AMI组患者hs-CRP水平与γ-GGT水平均呈正相关(r=0.355,0.170,P<0.05)。结论 ACS患者血清hs-CRP和γ-GGT水平显著升高;血清γ-GGT与hs-CRP可作为预测ACS的标志物。

Objective To investigate the changes in the levels of serum high sensitive C reaction protein（ hs-CRP） andγ-glutamyl transpeptidase（ γ-GGT） in patients with acute coronary syndrome（ ACS）. Methods Eighty patients with ACS were selected from October 2013 to December 2014 in the First People＇s Hospital of Yibin City. Among the patients,there were41 patients with unstable angina（ UA）（ UA group） and 39 patients with acute myocardial infarction（ AMI）（ AMI group）. Forty healthy people were selected in the same time as control group. The levels of serum hs-CRP and γ-GGT were compared among the three groups. Results The levels of serum hs-CRP and γ-GGT in UA and AMI group were significantly higher than those in control group（ P 〈0. 01）. The levels of serum hs-CRP and γ-GGT in AMI group were significantly higher than those in UA group（ P 〈0. 05）. The level of hs-CRP was positively correlated with the level of γ-GGT in UA and AMI group（ r = 0. 355,0. 170,P 〈0. 05）. Conclusions The levels of serum hs-CRP and γ-GGT increase significantly in patients with ACS. Serumγ-GGT and hs-CRP can be used as markers for predicting ACS.