1Bertina RM,Koelemen BPC, Koster T, et al. Mutation in blood coagulation factor V associated with resistance to activated protein C [J]. Nature, 1994,369(6475) :64-67.
2Nicolaes GA, Dahlback B. Factor V and thrombotic disease: description of a janus-faced protein [ J ]. Arterioscler Thromb Vasc Biol,2002,22(4) :530-538.
3Nicolaes GA, Dahlback B. Activated protein C resistance (FV (Leiden)) and thrombosis: factor V mutations causing hypercoagulable states [ J ]. Hematol Oncol Clin North Am, 2003,17(1) : 37-61.
4Crowther MA, Kelton JG. Congenital thrombophilic states associated with venous thrombosis: a qualitative overview and proposed classification system [ J]. Ann Intern Med, 2003,138 (2) :128-134.
6Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden [J]. Lancet, 1995,346(8983) :1133-1134.
7Margaglione M, Brancaccio V, De lucia D, et al. Inherited thrombophilic risk factors and venous thromboembolism: distinct role in peripheral deep venous thrombosis and pulmonary embolism [ J ]. Chest,2000,118 (5) : 1405-1411.
8Zalavras ChG,Giotopoulou S,Dokou E, et a/. Prevalence of the G20210A prothrombin gene mutation in Northwestern Greece and association with venous thromboembolism [ J]. Int Angiol,2003, 22(1) :55-57.
9Dowling NF, Austin H, Dilley A, et al, The epidemiology of venous thromboembolism in Caucasians and Mrican-Americans: the GATE study [ J ]. J Thromb Haemost,2003,1 ( 1 ) :80-87.
10Angchaisuksiri P, Pingsuthiwong S, Aryuchai K, et al. Prevalence of the G1691A mutation in the factor V gene (factor V Leiden) and the G20210A prothrombin gene mutation in the Thai population [ J ]. Am J Hemato1,2000,65 (2) : 119-122.
3De Stefano V,Martinelli I,Leone G,et al.The risk of recurrent deep venous thrombosis among heterozygous carriers of both factor Ⅴ Leiden and the G20210A prothrombin mutation.N Eng J Med,1999,341(11):801.
4Gerhardt A,Scharf RE,Beckmann MW,et al.Prothrombin and factor Ⅴ mutations in women with a history of thrombosis during pregnancy and the puerperium.N Eng J Med,2000,342(6):374.
5Rosendaal FR,Doggen CJM,Zivelin A,et al.Geographic distribution of the 20210 G to a prothrombin variant.Thromb Haemost,1998,79 (4):706.
6Mansourati J,Da Costa A,Munier S,et al.Prevalence of factor Ⅴ Leiden in patients with myocardial infarction and normal coronary angiography.Thromb Haemost,2000,83(6):822.
7Linfert DR,Rezuke WN,Tsongalis GJ.Rapid multiplex analysis for the Factor V Leiden and prothrombin G20210Amutations associated with hereditary thrombophilia.Conn Med,1998,62(9):519.
8Dahlback B,Hildebrand B.Inherited resistance to activated protein C is corrected by anticoagulant cofactor activity found to be a property of factor Ⅴ.Proc.Natl.Acad Sci USA,1994,91(4):1396.
9Gregg JP,Yamane A J,Grody WW.Prevalence of the factor Ⅴ-Leiden mutation in four distinct American ethnic populations.Am J Med Genet,1997,73(3):334.
10Gurgey A,Kudayarov DK,Tuncer M,et al.The factor Ⅴ Leiden and prothrombin G20210A mutations in Kirghiz population.Thromb Haemost,2000,84 (2):356.
