摘要
目的研究耐药真菌对抗真菌药物舍他康唑的药物敏感情况。方法 2015年6-8月于北京大学第一医院,参照美国临床实验室标准化协会(National Committee for Clinical Laboratory Standards,CLSI)推荐的M27-A3方案的微量液基稀释法,测量舍他康唑、伊曲康唑、咪康唑、克霉唑和氟康唑5种抗真菌药物对临床分离的120株耐药白假丝酵母菌、120株耐药光滑假丝酵母菌、30株敏感白假丝酵母菌株的最低抑菌浓度(MIC)。结果 (1)舍他康唑对白假丝酵母菌各耐药组的MIC值均高于非耐药组。(2)舍他康唑对光滑假丝酵母菌各耐药组的抗菌效果优于白假丝酵母菌组。结论舍他康唑在临床上治疗耐药光滑假丝酵母菌有一定的应用前景。
Objective To research the drug susceptibility differences of Sertaconazole against drug-resistant Candida spices. Methods Susceptibility testing of 120 drug-resistant Candida albicans, 120 Candida glabrata and 30 suscepti- ble Candida albieans were performed using the broth microdilution method (National Committee for Clinical Laboratory Standards, CLSI) between June and August of 2015 in Peking University First Hospital. Results (1) The minimal inhibi- tory concentrations (MICs) of sertaconazole against drug-resistant Candida albicans groups were higher compared with the susceptive group. (2) MICs of sertaconazole against drug-resistant Candida albicans groups were higher than the drug-resistant Candida glabrata ones.Conclusion Sertaeonazole may be used to treat drug-resistant Candida glabrata.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
2016年第4期353-356,共4页
Chinese Journal of Practical Gynecology and Obstetrics
关键词
舍他康唑
耐药假丝酵母菌
最低抑菌浓度
Sertaconazole
drug-resistant Candida spices
minimal inhibitory concentrations