摘要
目的探讨TGF-β1-509C/T基因多态性与维、汉民族颅内动脉瘤患者的发病关系及临床意义。方法选取临床确诊的120例动脉瘤患者(维吾尔族、汉族患者各60例)作为病例组,随机抽取该地区60例健康人群作为健康组,测定两组TGF-β1 509基因片段,对比分析两组基因多态性差异。结果病例组TGF-β1-509C/T基因型TT、TC、CC及T等位基因分布频率和对照组相比无显著性差异(P>0.05),且维吾尔族和汉族之间的分布没有显著性差异(P>0.05)。结论新疆维吾尔族和汉族颅内动脉瘤形成与TGF-β1基因-509C/T多态性无直接的相关性。TGF-β1-509位点可能不是新疆维吾尔族和汉族人群颅内动脉瘤的易感位点。
Objective To observe the correlation of TGF-β1 gene-509-C/T polymorphism and the formation of intracranial aneurysms in people with the Han and Vighur. Methods 120 cases Diagnosed with intracranial aneurysm were selected as case group, which control 60 patients in both Han and Vighur group and 60 case of healthy people as health group. TGF-β1 509-C/T was measured and compared the genetic polymorphisms in two groups. Results There is no direct relationship between TGF-β1 gene-509-C/T polym or phismand intracranial aneurysm formation in Xinjiang Uygur and Han Chinese（P〉0.05）. Conclusion There is no direct relationship between TGF-β1 gene-509-C/T polymorphism and Intracranial aneurysm formation in Xinjiang Uygur and Han Chinese. TG-β1-509 may not be susseptibility loci of intracranial aneurysm in Xinjiang Uygur and Han population.
出处
《临床医学研究与实践》
2016年第4期1-3,共3页
Clinical Research and Practice
基金
新疆维吾尔自治区自然科学基金(No.2013211A096)
关键词
颅内动脉瘤
TGF-Β1
基因多态性
民族差异
intracranial aneurysm
TGF-β1
gene polymorphism
race and ethnicity related differences
