美洛西林钠联合布拉氏酵母菌治疗感染性腹泻患儿的临床观察

Clinical Observation of Infantile Infectious Diarrhea Treated with Mezlocillin Combined with Saccharomyces boulardii

目的:观察美洛西林钠联合布拉氏酵母菌治疗感染性腹泻患儿的疗效及安全性。方法:96例感染性腹泻患儿按随机数字表法分为观察组和对照组,各48例。对照组患儿给予美洛西林钠75 mg/kg,tid;观察组患儿在对照组的基础上给予布拉氏酵母菌250 mg,bid。两组患儿均治疗72 h后评估疗效,比较两组患儿止泻时间、痊愈时间,并观察治疗前后大便次数、临床疗效及不良反应。结果:观察组患儿止泻时间及痊愈时间较对照组明显缩短,差异具有统计学意义(P<0.05)。治疗后24、72 h两组患儿大便次数较治疗前明显减少,且治疗后72 h观察组患儿大便次数明显少于对照组,差异有统计学意义(P<0.05)。观察组患儿总有效率(95.8%)明显高于对照组(83.3%),差异具有统计学意义(P<0.05)。观察组患儿出现便秘1例,对照组患儿出现皮疹1例,未经特殊治疗均自行痊愈。结论:美洛西林钠联合布拉氏酵母菌治疗感染性腹泻患儿疗效显著,且安全性较好。

OBJECTIVE：To observe therapeutic efficacy and safety of infantile infectious diarrhea treated with mezlocillin combined with Saccharomyces boulardii. METHODS：96 patients with infantile infectious diarrhea were randomly divided into control group and observation group with 48 patients in each group. In control group,the patients were given mezlocillin,75 mg/kg,tid.On this basis,the patients in observation group were given S. boulardii 250 mg,bid. Antidiarrheal time and healing time were compared between 2 group after 72 h,and bowel movement frequency,clinical efficacy and security were observed before and after treatment. RESULTS：Antidiarrheal time and healing time of observation group were significantly shorter than those of control group,with statistical significance（P〈0.05）. 24 and 72 h after treatment,bowel movement frequency in 2 groups were reduced obviously;that of observation group was significantly less than control group 72 h after treatment,with statistical significance（P〈0.05）. The effective rate of observation group（95.8%）was significantly higher than that of control group（83.3%）,with statistical significance（P〈0.05）. There was 1 case of constipation in observation group and 1 case of erythra in control group. Both groups were cured without special treatment. CONCLUSIONS：Mezlocillin combined with S. boulardii could cure infantile infectious diarrhea effectively and shorten the time of diarrhea and healing time,with good safety.