血清维生素D水平与活动性肺结核患病的相关性

The relationship between serum vitamin D level and activity tuberculosis

目的评价活动性肺结核患者血清维生素D的水平，并探讨其与结核病患病的相关性。方法选取天津市海河医院2011-2014年的初治活动性肺结核患者90例作为肺结核组，及同期在本院正常成年人进行体格检查者40名作为对照组，应用酶联免疫法进行血清25一羟基维生素D[25-（OH）VD]浓度测定，分析肺结核组和对照组差异。同时，将肺结核组按照病变严重程度又分为轻度、中度、重度组，并对各组血清25一羟基维生素D水平进行比较。结果肺结核组血清25-羟基维生素D浓度为（21．740±4．546）nmol／L，低于对照组的（25．236±4．435）nmol／L，差异有统计学意义（产4．08，PH0．05）。将肺结核组90例患者按照病变范围轻度、中度、重度的标准分为3组，其中轻度组25例，血清25-（OH）VI）浓度为（24．164±4．547）nmoi／L；中度组25例，浓度为（24．827±6．896）nmol／L；重度组40例，浓度为（20．883±3．805）nmol／L。各组比较，差异有统计学意义（F=4．04，PH0．05）；进一步的两两比较显示，轻度组25-（OH）VD浓度高于重度组（q=3．51，P〈0．05）；中度组血清25-（0H）VD）浓度高于重度组（q=3．70，P〈0．05）。结论活动性结核病患者血清中维生素D的水平明显低于正常成年人，维生素D水平不仅与肺结核的患病存在关联，并且与肺结核病变严重程度存在关联。

Objective To evaluate the level of serum vitamin D in activity pulmonary tuberculosis patients, and to explore its relationship with the severity of pulmonary tuberculosis. Methods Ninety hospitalized patients of activity pulmonary tuberculosis （test group） and 40 healthy adults （control group） were enrolled in Haihe hospital in Tianjin City from 2011 to 2013. 25-hydroxy-vitamin D levels in serum was tested by enzyme linked immunosor bent assay. To compare with the 25-hydroxy-vitamin D levels between activity pulmonary tuberculosis patients and health adults. Meanwhile, The relationship between the 25-hydroxy-vitamin D levels and the severity of pulmonary tuberculosis was compared. Results The serum 25-hydroxy-vitamin D levelsin test group （21. 740±4. 546） nmol/L was lower than that in control group （25. 236±4. 435） nmol/L, t： 4.08, P〈0.05. Furtherly, the test group was divided into 3 groups according to their severity of disease. The serum 25-hydroxy-vitamin D levels was （24. 164± 4. 547） nmol/L in mild group （25 patients）; （24. 827 ± 6. 896） nmol/L in moderate group （25 patients） and （20. 883±3. 805） nmol/L in severe group （40 patients）, respectively. There are the significant statistical differences among three groups （F=4.04, P〈0.05）. Comparison of two groups, the serum 25-hydroxy-vitamin D levels was higher in mild groupthan that in severe group （q=3.51, P〈0.05）, and the serum 25-hydroxy-vitamin D levels was higher in moderate group than that in severe group （q= 3.70, P〈0.05）. Conehtsion The serum 25-hydroxy- vitamin D levels of activity pulmonary tuberculosis patients is obviously lower than that in heslthy adults. Also, the serum level of vitamin D in TB patients is associated with the severity of pulmonary tuberculosis.