活膝汤联合臭氧关节腔注射治疗膝关节骨性关节炎临床研究

Clinical Study of Treatment of Knee Osteoarthritis by Combination of Huoxi Decoction and Intra-articular Injection of Ozone

目的 :探讨活膝汤联合臭氧治疗膝关节骨性关节炎(KOA)的临床疗效。方法 :90例KOA患者随机分为三组各30例,联合用药组采用活膝汤内服+臭氧关节腔注射;臭氧注射组单纯采用臭氧关节腔注射;活膝汤组单纯采用活膝汤内服。共治疗1个月,评价治疗前后患者骨性关节炎指数评分量表(WOMAC)评分、疼痛视觉模拟评分法(VAS)评分及综合疗效。结果:三组患者疼痛VAS评分、WOMAC评分,治疗前后差异均有统计学意义(P<0.05);综合疗效,联合治疗组总有效率96.7%;臭氧组总有效率90.0%;活膝汤组总有效率80.0%,三组间疗效差异有统计学意义(P<0.05)。结论:活膝汤联合臭氧治疗膝关节骨性关节炎可明显缓解临床症状,改善关节功能,且疗效优于单独臭氧关节腔注射和活膝汤内服。

Objective：To explore the clinical curative effect of Huoxi decoction combined with intra-articular injection of ozone on knee osteoarthritis（KOA）. Methods：A total of 90 cases of KOA patients were randomly divided into three groups,with 30 cases in each group.The combined treatment group was treated with oral administration of Huoxi decoction combined with intra-articular injection of ozone. The ozone injection group was treated with intra-articular injection of ozone and the Huoxi decoction group was treated with oral administration of Huoxi decoction.The treatment time was one month. The WOMAC osteoarthritis index scores,visual analog scale（VAS） scores and comprehensive curative effects before and after treatment were evaluated. Results：After treatment,the differences of VAS and WOMAC scores of the three groups was statistically significant（P〈0.05）. For the comprehensive curative effects,in the combined treatment group,the total effective rate was 96.7%. In the ozone group,the total effective rate was 90.0%. In the Huoxi decoction group,the total effective rate was 80.0%. The difference of curative effects among the three groups was statistically significant（P〈0.05）. Conclusion：Huoxi decoction combined with ozone can relieve the clinical symptoms of KOA,improve the knee function,and the effect is better than that of single ozone injection and individual Huoxi decoction therapy.