乳腺癌骨转移中医证候规律调查

Research on Chinese Medicine Syndrome Regulation of Bone Metastasis of Breast Cancer

目的:探讨乳腺癌骨转移的中医病因病机、证候及辨证分型标准,为科研及临床工作提供基础性研究。方法:调查110例乳腺癌骨转移患者的临床症状及舌象、脉象,填写乳腺癌骨转移中医证候规律研究调查表,采用SPSS建立四诊信息数据库,运用描述性分析、频数分析、聚类分析等方法进行统计分析,依据专业知识,结合中医理论,总结出各证型的主要症状、舌脉。结果:1.乳腺癌骨转移的常见6类证型分别为:阳虚寒凝证、气滞血瘀证、痰湿流注证、肝肾阴虚证、热毒内结证、气血亏虚证。2.乳腺癌骨转移的主要症状为局部胀痛或酸痛,疼痛持续,痛处固定,形体消瘦,动作迟缓,倦怠乏力,食少纳差等。结论:初步揭示了乳腺癌骨转移的中医证候分布规律,有利于指导中医辨证以及临床治疗。

Objective：To discuss Chinese Medicine（CM） etiology and pathogenesis,syndrome differ classification standards of bone metastasis of breast cancer,and provide basis research for scientific research and clinical practice. Methods：Surveyed clinical symptoms,tongue and pulse condition of 110 cases of patients with bone metastasis of breast cancer,and filled in the investigation tables of CM syndrome regulation of bone metastasis;established four diagnostic information database with SPSS software;made a statically analysis by the methods of descriptive analysis,frequency analysis,cluster analysis etc.;and then summarized the cardinal symptom and tongue, pulse of every syndrome, combining with the CM theories according to professional knowledge. Results：The common 6 types of syndromes of bone metastasis of breast cancer include：syndrome of yang deficiency and coagulated cold,syndrome of qi stagnation and blood stasis,syndrome of phlegm- damp and gravitational abscess,syndrome of yin deficiency of liver and kidney,syndrome of toxic heat stagnating in the body,syndrome of qi and blood deficiency. The cardinal symptom of bone metastasis of breast cancer is regional swelling pain or aching pain,duration of pain,fixed pain point,emaciation,bradykinesia,listlessness,loss of appetite etc. Conclusion：It reveals preliminarily CM syndrome distribution regulations of bone metastasis of breast cancer,and is beneficial to guide CM differentiation and clinical treatment.