胃肠胰神经内分泌肿瘤的临床病理分析

Clinical and Pathological Analysis of Gastroenteropancreatic Neuroendocrine Neoplasms

目的:分析胃肠胰神经内分泌肿瘤(GEP-NENs)的临床病理。方法:随机抽取GEP-NENs患者55例,对患者临床病理特征予以分析。结果:肿瘤原发部位为直肠、胰腺、胃、阑尾、十二指肠、结肠及输卵管。78.2%为非功能性神经内分泌肿瘤(NENs),21.8%为功能性NENs。内镜检出率为97.6%,见黏膜溃疡、隆起或出现菜花状赘生物。G1级50.9%,G2级32.7%,G3级16.4%。神经内分泌瘤(NET)为76.4%,神经内分泌癌(NEC)为20.0%,混合性腺神经内分泌癌(MANCE)为3.6%。结论:消化道任何部位均可发生GEP-NENs,应采取病理诊断确定。

Objective To analyze the clinical and pathological changes of GEP-NENs in gastrointestinal tract. Methods55 cases of GEP-NENs patients were randomly selected, and the clinical pathological characteristics were analyzed. ResultsThe primary tumor site was located at rectum, pancreas, stomach, appendix, duodenum, colon and fallopian tube. 78.2 % for the non functional NENs, 21.8 % for the functional NENs. Endoscopic detection rate was 97.6 %, mucosal ulcer, uplift or caulifl ower excrescence. Class GI 50.9 %, class G2 32.7 %, class G3 16.4 %. NET was 76.4 %, NEC was 20 %, MANCE was 3.6 %.Conclusion GEP-NENs can occur in any part of the digestive tract, which should be confi rmed by pathological diagnosis.