固冲止崩汤联合妈富隆治疗更年期功能性子宫出血的临床疗效

Clinical efficacy of Guchong Zhibeng decoction combined with marvelon in the treatment of menopausal dysfunctional uterine bleeding

目的:探讨固冲止崩汤联合妈富隆与单独妈富隆治疗更年期功能性子宫出血的临床疗效及安全性。方法:将更年期功能性子宫出血患者118例随机分两组,对照组59例采用妈富隆治疗,治疗组59例采用固冲止崩汤联合妈富隆治疗,比较两组临床疗效与安全性。结果:治疗后,两组促卵泡生成素、黄体生成素、孕酮、雌二醇降低(P<0.05)。治疗组促卵泡生成素、黄体生成素、孕酮、雌二醇、复发率低于对照组(P<0.05),控制出血时间、完全止血时间、月经规律时间早于对照组(P<0.05),临床疗效高于对照组(P<0.05)。两组药物不良反应(恶心呕吐、食欲不振、头晕头痛)比较,差异无统计学意义(P>0.05)。结论:固冲止崩汤联合妈富隆治疗更年期功能性子宫出血的疗效更佳,安全性高且复发率低,值得临床使用。

Objective：To investigate the clinical efficacy and safety of the use of Guchong Zhibeng decoction combined with marvelon and only the use of marvelon in the treatment of menopausal dysfunctional uterine bleeding.Methods：118patients with menopausal dysfunctional uterine bleeding were randomly divided into two groups,59 patients in control group were treated with marvelon,and 59 patients in treatment group were treated with Guchong Zhibeng decoction combined with marvelon.The clinical efficacy and safety of the two groups were compared.Results：The follicle stimulating hormone,luteinizing hormone,progesterone,and estradiol in the two groups were decreased after treatment（P？0.05）.The recurrence of follicle stimulating hormone,luteinizing hormone,progesterone,and estradiol in the treatment group was lower than that of the control group（P？0.05）,the hemorrhage control time,complete hemostasis time,and regular menstruation time in treatment group were earlier than that of the control group（P？0.05）,and the clinical efficacy in treatment group was higher than that of the control group（P？0.05）.Compared the drug adverse reactions（nausea and vomiting,loss of appetite,dizziness and headache）in the two groups,the difference has no statistical significance（P 〈0.05）.Conclusion：Guchong Zhibeng decoction combined with marvelon has a better curative effect in the treatment of menopausal dysfunctional uterine bleeding,a high safety and a low recurrence rate.So it is worthy of clinical use.