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BTBD10基因的研究现状与进展

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摘要 BTBD10基因属于BTB/POZ家族,在多种正常组织中都有表达。其主要通过调节Akt磷酸化水平来改变后续信号通路,产生一系列生物学效应,包括可能参与基因的表达调控,生物体增殖、分化、凋亡等重要过程。目前发现:BTBD10在脑胶质瘤中的表达与肿瘤恶性程度有关,视为潜在的抑癌基因。同时,其在调节胰岛β细胞增殖和凋亡,颅内出血后脑损伤进程及家族性肌萎缩脊髓侧索硬化(ALS)的发病机制中均有作用。随着研究深入,将更加详细了解其多样化的生物学功能和具体作用机制。
作者 施栋良(综述) 黄仁强(综述) 卢亦成(审校)
机构地区 第二军医大学长征医院神经外科
出处 《中国微侵袭神经外科杂志》 CAS 2016年第3期142-144,共3页 Chinese Journal of Minimally Invasive Neurosurgery
关键词 BTBD10基因 神经胶质瘤 胰岛Β细胞 脑损伤 肌萎缩侧索硬化 家族性
分类号 R739.45 [医药卫生—肿瘤]
  • 相关文献

参考文献16

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二级参考文献44

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中国微侵袭神经外科杂志
2016年 第3期

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