布地奈德吸入剂量对治疗咳嗽变异型哮喘的影响

The effect of budesonide inhalation dose for the treatment of cough variant asthma

目的探讨吸入不同剂量布地奈德对治疗咳嗽变异型哮喘临床疗效的影响。方法 126例于我院就诊并接受治疗的咳嗽变异型哮喘患者纳入本研究,随机均分为试验组和对照组,试验组接受吸入小剂量布地奈德,对照组则大剂量吸入布地奈德;治疗结束时对比两组患者的临床疗效和不良反应、第一秒用力呼气容积占预计值的百分比、最大呼气流速、嗜酸性粒细胞百分数和咳嗽症状评分。结果两组患者治疗后临床疗效和不良反应发生率并无差异(P>0.05),但第一秒用力呼气容积占预计值的百分比、最大呼气流速、嗜酸性粒细胞百分数和咳嗽症状评分试验组均明显优于对照组(P<0.05)。结论大剂量布地奈德雾化吸入与小剂量雾化吸入治疗临床疗效和不良反应相似,但大剂量更能有效改善患者肺功能和炎症反应,临床应首先考虑应用。

Objective To investigate the effect of budesonide inhalation dose for the treatment of cough variant asthma.Methods 126 patients with cough variant asthma were collected,randomly divided into test and control groups,the former accepted high dose inhaled budesonide,and low dose for the latter; the clinical efficacy,adverse reactions,FEV1%pre,PEF,the percentage of eosinophils and cough scores were compared. Results There＇s no different in clinical efficacy and the incidence of adverse effects（ P〉0. 05）; but the FEV1% pre,PEF,the percentage of eosinophils and cough scores in the test group were significantly better than the control group（ P〈0. 05）. Conclusion High and low dose inhaled budesonide has the same clinical efficacy and adverse reactions,but high doses is more effective in improving lung function and inflammation,clinical application should be considered first.