补阳还五汤加减对下肢骨科手术后气虚血瘀证患者凝血和血液流变学指标的影响

Effect of Buyanghuanwu Decoction on Coagulation and Hemorheology Indexes in Patients Underwent Lower Limb Orthopedic Operation with Qi Deficiency Blood Stasis

目的:观察补阳还五汤加减口服对下肢骨科手术后气虚血瘀证患者凝血及血液流变学指标的影响,观察下肢深静脉血栓(DVT)的阳性率。方法:选取下肢骨科手术后气虚血瘀证患者90例,按入组先后顺序分为治疗组和对照组各45例,两组术后均采用常规方法预防DVT,治疗组加用补阳还五汤加减口服治疗,治疗10d后观察凝血、血液流变学指标变化情况及DVT阳性率。结果:治疗10d后,治疗组在凝血酶原时间(PT)、纤维蛋白原(FIB)及D-二聚体(D-D)等凝血指标和血液流变学指标方面与对照组相比差异具有显著性(P<0.01),两组在DVT阳性率方面差异亦具有统计学意义(P<0.01)。结论:补阳还五汤加减口服能改善下肢骨科手术后气虚血瘀证患者血栓前状态,降低DVT发生率。

Objective：To observe the effect of modified Buyanghuanwu decoction on coagulation and hemorheology indexes in patients underwent lower limb operation with Qi deficiency blood stasis,then calculate the positive rate of deep vein thrombosis（DVT）.Methods：90patients with Qi deficiency blood stasis after lower limb operation were divided into treatment group and control group according to chronological order,45 cases in each group.Conventional method was used to prevent postoperative DVT in both groups,and the treatment group took modified Buyanghuanwu decoction orally at the same time.Changes of coagulation and hemorheology indexes as well as the positive rate of DVT were observed 10 dafter treatment.Results：After treatment for 10 d,the PT,FIB and D-D and other coagulation and hemorheology indexes in treatment group were significantly different compared with the control group（P〈0.01）,the DVT positive rate difference was also statistically significant（P〈0.01）.Conclusion：Modified Buyanghuanwu decoction can improve prethrombosis state in patients with Qi deficiency blood stasis after lower limb operation,so as to reduce the incidence of DVT.