摘要
目的探讨2型糖尿病(T2DM)高尿酸血症患者的一般生化及胰岛素相关指标变化情况。方法选取我院281例T2DM住院患者,按男性和绝经后女性SUA≥417μmol/L,绝经前女性SUA≥356μmol/L,将其分为正常尿酸(NUA)组250例与高尿酸(HUA)组31例,观察甘油三酯(TG)、总胆固醇(CHOL)低密度脂蛋白胆固醇(LDL-C)、血清尿酸(SUA)、肌酐(Cr)、空腹血糖(FPG)、糖化血红蛋白(HBA1C)、空腹C-肽(FC-P)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA IR)、胰岛素敏感性指数(ISI)等指标情况,并计算病程、收缩压(SBP)、舒张压(DBP)及体重指数(BMI)。结果两组BMI,TG,LDL-C,Cr,FINS,FC-P,ISI,HOMA-IR等指标相比较差异均有统计学意义(P<0.05)。相关分析的结果显示,SUA与体重指数、血脂、肾功、FC-P、HOMA IR、ISI存在相关性(P<0.05)。结论 T2DM合并高尿酸血症与高血压、血脂异常、肥胖、胰岛素抵抗存在显著相关性。
Objective To investigate the factors relating to hyperglycemia in type 2 diabetic patients and the risk factors of hyperglycemia. Methods 281 cases of hospitalized patients with T2 DM were selected and divided into normal serum uric acid（ NUA） group（ n = 250） and hyperglycemia（ HUA） group（ n = 31） in terms of serum uric acid levels. The levels of TG,CHOL,LDL-C,SUA,Cr,FPG,HBA1 C,FC-P,FINS,HOMA IR,ISI were observed. And the duration,systolic blood pressure（ SBP）,diastolic blood pressure（ DBP） and body mass index（ BMI） were calculated. Results There were statistically significant differences in BMI,TG,LDL-C,Cr,FINS,FC-P,ISI,HOMA IR between the two groups（ P〈0. 05）. Correlation analysis showed that the SUA was correlated with BMI,lipids,renal function,HOMAIR,FC-P and ISI（ P〈0. 05）. Conclusion The level of hyperglycemia in patients with T2 DM is closely related to hypertension,dyslipidemia and adiposity.
出处
《潍坊医学院学报》
2016年第2期135-137,共3页
Acta Academiae Medicinae Weifang
