血浆脂蛋白相关磷脂酶A2与大动脉粥样硬化性脑梗死患者颈动脉狭窄程度的相关性

The correlation between plasma Lp-PLA2 and the degree of carotid stenosis in patients with atherosclerotic cerebral infarction

【目的】探讨血浆脂蛋白相关磷脂酶A2(lipoprotein associated phospholipase A2,Lp-PLA2)与大动脉粥样硬化性脑梗死患者颈动脉狭窄程度的关系。【方法】选取急性大动脉粥样硬化性脑梗死患者160例为病例组,按颈部血管超声、经颅多普勒或主动脉弓上-颅内CTA检查结果分为颈动脉轻中度狭窄组和颈动脉重度狭窄组,各80例。对照组选取基线资料与病例组相匹配的健康体检者80例。采用双抗体夹心酶联免疫吸附法检测病例组与对照组血浆Lp-PLA2水平,同时检测血脂相关指标。【结果】颈动脉轻中度狭窄组及重度狭窄组患者血浆Lp-PLA2水平均明显高于对照组(P<0.01);颈动脉重度狭窄患者血浆LpPLA2水平明显高于颈动脉轻中度狭窄组(P<0.01)。【结论】Lp-PLA2可能与大动脉粥样硬化性脑梗死颈动脉狭窄程度有关,可作为预测大动脉粥样硬化性脑梗死颈动脉狭窄程度的一个生物学标志物。

【Objective】To explore the relationship between plasma lipoprotein associated phospholipase A2（Lp-PLA2） and the degree of carotid stenosis in patients with atherosclerotic cerebral infarction.【Methods】A total of 160 patients with acute atherosclerotic cerebral infarction were selected into case group. According to the results of cervical vascular ultrasound, transcranial Doppler（TCD） or aortic arch- intracranial cavity CTA, the cases were divided into mild or moderate carotid stenosis group and severe carotid stenosis group,80 cases per group. In control group, 80 healthy volunteers with physical examination were selected whose baseline data matched those in case group. Plasma Lp-PLA2 levels were determined with double antibody sandwich enzyme-linked immunosorbent assay（ELISA）,and indexes related to blood lipid were also detected.【Results】The plasma Lp-PLA2 levels in mild or moderate carotid stenosis group and severe carotid stenosis group were significantly higher than that in control group（P〈0.01）. The plasma Lp-PLA2 levels in patients with severe carotid stenosis were significantly higher than those in patients with mild or moderate carotid stenosis（P〈0.01）.【Conclusion】Lp-PLA2 may be related to the degree of carotid stenosis in patients with atherosclerotic cerebral infarction. It can be used as a biological marker for the prediction of carotid stenosis in atherosclerotic cerebral infarction.