内脂素、高敏C反应蛋白与儿童单纯性肥胖的相关性

Visfatin, high-sensitivity C-reactive protein in children with simple obesity

【目的】探讨单纯性肥胖儿童血浆内脂素、高敏C反应蛋白(high-sensitivity reaction protein,hs CRP)水平与肥胖发生发展的关系。【方法】采用酶联免疫法、免疫比浊法测定42例单纯性肥胖儿童,20例正常对照儿童的血浆内脂素、hs CRP水平。并分析血浆内脂素、hs CRP与体质指数(body mass index,BMI)、腰臀比(waist hip ratio,WHR)及空腹血糖、空腹胰岛素水平、胰岛素抵抗指数(homeostasis model assessment ratio,HOMA-IR)、胰岛素敏感性指数(insulin sensitivity index,ISI)及血脂的关系。【结果】(1)肥胖组血浆内脂素、hs CRP(31.51±5.70、1.94±0.97)明显高于对照组(21.33±2.70、1.16±0.40)(P<0.001)。(2)内脂素、hs CRP与BMI、WHR、空腹血糖、总胆固醇、胰岛素水平和HOMA-IR呈正相关(P<0.01),与ISI呈负相关(P<0.01);内脂素与hs CRP呈正相关(P<0.05)。(3)多元逐步回归分析表明BMI为影响内脂素、hs CRP的因素。【结论】血浆内脂素水平、hs CRP与肥胖程度、脂肪分布、糖、脂代谢密切相关,提示内脂素、hs CRP可能与儿童肥胖的发生发展密切相关。

【Objective】To investigate the possible correlation between obesity and visfatin and hs CRP in obese children.【Methods】42obese children and 20 normal controls were enrolled. The plasm concentration of visfatin and hs CRP（high-sensitivity reaction protein）was measured with euzymelinked immunosorbent assay and immunoturbidimetry. Statistic analysis was made to explore the relationship between visfatin, hs CRP and body mass index（BMI）, waist hip ratio（WHR）,fasting glucose（FPG） and fasting insulin（FINS）, Homeostasis model assessment ratio（HOMR-A）, Insulin sensitivity index（ISI）,plasma lipid. Correlation analysis was performed between visfatin, hs CRP and other parameters.【Results】（1）The plasm visfatin, hs CRP concentration of obese children objectly is higher than normal controls（ P〈0.01）.（2）There was an obviously positive correlation between visfatin, hs CRP and BMI, WHR, FBS, FINS, HOMR-A（P〈0.01）. There was an obviously negative correlation between visfatin and hs CRP and ISI（P〈0.01）. There were obviously positive correlation between visfatin and TC（P〈0.01）. There were positive correlation between hs CRP and TC（P〈0.05）. There were positive correlation between visfatin and hs CRP（P〈0.05）.（3）Multiple stepping regression analysis suggested that BMI was the factor that significantly influenced visfatin and hs CRP.【Conclusion】The plasm visfatin and hs CRP concentration significantly correlated with the degree of obesity and the distribution of fat and metabolism of glucose and lipid. Visfatin and hs CRP is probably related to occurrence and development of obesity in children.