摘要
目的:探讨中药肿节风联合金因肽在放射性口腔黏膜炎患者中的临床治疗效果。方法:选取2015年1月—2015年10月广西壮族自治区桂林医学院附属医院诊治的80例放射性口腔黏膜患者,随机将患者分为对照组和试验组,对照组采用金因肽治疗,试验组在对照组基础上联合中药肿节风颗粒治疗,比较两组临床疗效。结果:试验组总有效率为95%,显著高于对照组(85%)(P<0.05);试验组放射性口腔黏膜炎愈合时间、疼痛评分,显著低于对照组(P<0.05)。治疗后,两组患者血清指标均下降,试验组的TNF-α、IL-6、IL-8低于对照组,差异有统计学意义(P<0.05)。结论:放射性口腔黏膜炎治疗时在金因肽治疗基础上联合中药肿节风治疗效果显著,值得推广应用。
Objective： To investigate the effect of Sarcandra glabra combined with Recombinant Human Epidermal Growth Factor Derivative For External Use for the treatment of patients with radioactive oral mucositis. Methods： From January 2015 to October 2015, 80 cases with radioactive oral mucositis were analyzed. The patients were randomly divided into control group and experimental group. The control group was treated with Recombinant Human Epidermal Growth Factor Derivative For External Use, and the experimental group was treated with Chinese medicine combined with traditional Chinese medicine on the basis of the control group. The clinical efficacy of the two groups was compared. Results： The total effective rate of the experimental group was 95%, significantly higher than that of the control group（85%）（P 0.05）. The healing time and pain score were significantly lower in the experimental group than those of the control group（P 0.05）. Before treatment, the levels of serum TNF-, IL-6 and IL-8 were not significantly different between the two groups with no statistical significance（P〈0.05）; after treatment, the serum levels of the two groups were decreased, the IL-6, IL-8 and TNF- in the experimental group were significantly lower than those in the control group with significant difference（P〈0.05）. Conclusion： Radioactive oral mucositis treatment with Recombinant Human Epidermal Growth Factor Derivative For External Use combined with traditional Chinese medicine Zhongjiefeng can achieve ideal treatment effect, improve oral mucosa protection and it＇s worth popularization and application.
出处
《临床药物治疗杂志》
2016年第2期37-39,共3页
Clinical Medication Journal
基金
广西壮族自治区卫生厅自筹经费科研课题(Z2013487)
