摘要
目的 :探讨维生素D受体(VDR)基因多态性与1型糖尿病(T1D)易感性的关系。方法 :通过检索Pub Med、Web of Science、Wan Fang等数据库中获得有关VDR基因多态性与T1D易感性病例-对照关联研究的文献,计算相关基因位点的OR值和95%的可信区间(CI)。结果:共纳入37篇,研究间有异质性,采用随机效应模型合并,BsmⅠ和ApaⅠ多态性是T1D的易感基因(B vs b:OR=1.10,95%CI:1.04~1.18,P=0.003,AA vs aa:OR=1.24,95%CI:1.05~1.48,P=0.012),而FokⅠ和TaqⅠ多态性与T1D的易感性无关。按种族区域进行亚组分析发现,BsmⅠ多态性是东亚和拉丁美洲T1D的易感基因(B vs b分别为:OR=1.52,95%CI:1.33~1.74,P〈0.01;OR 1.51,95%CI:1.25~1.82,P〈0.001),ApaⅠ多态性是东亚T1D易感基因(AA vs aa:OR=1.99,95%CI:1.20~3.29,P=0.007)。结论:BsmⅠ和ApaⅠ多态性是东亚T1D的易感基因,且BsmⅠ有可能是拉丁美洲T1D的易感基因,而FokⅠ和TaqⅠ多态性与T1D易感性无关。
Objective:The vitamin D receptor(VDR)gene polymorphisms have been suggested to be involved in the development of type 1 diabetes(T1D). However,the results to date have been inconclusive. We performed a meta-analysis to examine the associations.Methods:Literature was retrieved from Pub Med,Web of Science and Chinese databases Wan Fang. Pooled odds ratios(ORs)with 95%confidence intervals(CIs) were calculated using a random effect model. Results:The results indicated that BsmⅠ and ApaⅠ were associated with an increased risk of T1D(B vs b:OR=1.10,95%CI:1.04~1.18,P=0.003,AA vs aa:OR=1.24,95%CI:1.05~1.46,P=0.012,),while the FokⅠ and TaqⅠ polymorphisms were not. In the subgroup analysis by ethnicity and area,the increase risk of T1 D remain in the East Asian and Latino subgroup for the BsmⅠ polymorphism(B vs b:OR=1.52,95%CI:1.33~1.74,P〈0.001 for East Asian;OR 1.51,95% CI:1.25 ~1.82,P〈0.001 for Latino),East Asian subgroup for the ApaⅠ polymorphism(AA vs aa:OR1.99,95%CI:1.20~3.29,P=0.007). Whereas no significant association was found in other population. Conclusion:Our meta-analysis suggests that the BsmⅠ and ApaⅠ polymorphism may be a risk factor for susceptibility to T1 D in Asians. Moreover,Bsm Ⅰpolymorphism may be a risk factor in Latinos. However,the FokⅠ and TaqⅠ polymorphisms are unlikely to be associated with increased T1 D risk in the populations investigated.
出处
《南京医科大学学报(自然科学版)》
CAS
CSCD
北大核心
2016年第2期251-256,共6页
Journal of Nanjing Medical University(Natural Sciences)
基金
连云港市卫生科技项目(局1402)