维生素D受体基因多态性与1型糖尿病易感性的meta分析

Associations between four polymorphisms(FokⅠ,ApaⅠ,BsmⅠ,TaqⅠ) of vitamin D receptor gene and type 1 diabetes:A meta-analysis

目的 ：探讨维生素D受体（VDR）基因多态性与1型糖尿病（T1D）易感性的关系。方法 ：通过检索Pub Med、Web of Science、Wan Fang等数据库中获得有关VDR基因多态性与T1D易感性病例-对照关联研究的文献,计算相关基因位点的OR值和95%的可信区间（CI）。结果：共纳入37篇,研究间有异质性,采用随机效应模型合并,BsmⅠ和ApaⅠ多态性是T1D的易感基因（B vs b：OR=1.10,95%CI：1.04~1.18,P=0.003,AA vs aa：OR=1.24,95%CI：1.05~1.48,P=0.012）,而FokⅠ和TaqⅠ多态性与T1D的易感性无关。按种族区域进行亚组分析发现,BsmⅠ多态性是东亚和拉丁美洲T1D的易感基因（B vs b分别为：OR=1.52,95%CI：1.33~1.74,P〈0.01;OR 1.51,95%CI：1.25~1.82,P〈0.001）,ApaⅠ多态性是东亚T1D易感基因（AA vs aa：OR=1.99,95%CI：1.20~3.29,P=0.007）。结论：BsmⅠ和ApaⅠ多态性是东亚T1D的易感基因,且BsmⅠ有可能是拉丁美洲T1D的易感基因,而FokⅠ和TaqⅠ多态性与T1D易感性无关。

Objective：The vitamin D receptor（VDR）gene polymorphisms have been suggested to be involved in the development of type 1 diabetes（T1D）. However,the results to date have been inconclusive. We performed a meta-analysis to examine the associations.Methods：Literature was retrieved from Pub Med,Web of Science and Chinese databases Wan Fang. Pooled odds ratios（ORs）with 95%confidence intervals（CIs） were calculated using a random effect model. Results：The results indicated that BsmⅠ and ApaⅠ were associated with an increased risk of T1D（B vs b：OR=1.10,95%CI：1.04~1.18,P=0.003,AA vs aa：OR=1.24,95%CI：1.05~1.46,P=0.012,）,while the FokⅠ and TaqⅠ polymorphisms were not. In the subgroup analysis by ethnicity and area,the increase risk of T1 D remain in the East Asian and Latino subgroup for the BsmⅠ polymorphism（B vs b：OR=1.52,95%CI：1.33~1.74,P〈0.001 for East Asian;OR 1.51,95% CI：1.25 ~1.82,P〈0.001 for Latino）,East Asian subgroup for the ApaⅠ polymorphism（AA vs aa：OR1.99,95%CI：1.20~3.29,P=0.007）. Whereas no significant association was found in other population. Conclusion：Our meta-analysis suggests that the BsmⅠ and ApaⅠ polymorphism may be a risk factor for susceptibility to T1 D in Asians. Moreover,Bsm Ⅰpolymorphism may be a risk factor in Latinos. However,the FokⅠ and TaqⅠ polymorphisms are unlikely to be associated with increased T1 D risk in the populations investigated.