2-N,N-双(2-羟基乙氧基乙基)氨基-4-乙酰氨基苯甲醚的合成工艺研究

Synthesis and Technique Optimization of 2-(N,N-bis((2-hydroxyethoxy)ethyl)amino)-4-acetamino)anisole

以2-氨基-4-乙酰氨基苯甲醚与2-(2-氯乙氧基)乙醇为原料合成了未见报道的化合物2-N,N-双(2-羟基乙氧基乙基)氨基-4-乙酰氨基苯甲醚。考察了不同的反应条件,如缚酸剂种类和用量、投料比、反应温度和催化剂等因素对产品收率和纯度的影响。优化条件下,产物收率79.9%,纯度98.7%。

New compound of 2-（N,N-bis（（2-hydroxyethoxy）ethyl）amino）-4-acetamino）anisole was synthesized by the reaction of 2-amino-4-acetamino anisole with 2-（2-chloroethoxy）ethanol. The effects of reaction conditions on the yield and purity were investigated, including the kinds of acid binding agent, the amount of acid binding agent, feed ratio, reaction temperature and catalyst. The results showed that yield of the product would increase with the weakening alkaline acid binding agent. And the yield rate of the product after the first increases and then decreases with the addition of amount of acid-binding agent, amount of 2-（2-chloroethoxy）ethanol and the reaction time.