摘要
以2-乙酰噻吩为原料,经Mannich反应、还原反应、手性拆分、光延反应合成(S)-(+)-N,N-二甲基-3-(1-萘氧基)-2-噻吩基丙胺。对反应物配料比、反应时间和温度等工艺影响因素进行了研究,总收率达40.26%(以2-乙酰噻吩计),其结构经1H NMR和MS确证。
(S)-(+)-N,N-Dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propylamine was synthesized in four steps Mannich reaction, reduction, chiral separation and mitsunobu reaction with yield of 40.26%. The factors including the ratio of raw materials, the reaction time and temperature were investigated. The structure was confirmed by ^1H NMR and MS spectra.
出处
《精细化工中间体》
CAS
2016年第1期39-42,共4页
Fine Chemical Intermediates
基金
湖北省教育厅科学研究计划项目(Q20141510)