摘要
以2-溴-1,4-二甲氧基-3-甲基萘和溴代香叶醇为起始原料,经偶联反应和烯丙位末端氧化反应得到维生素K_2（35）关键中间体,总收率为64.9%,其结构经MS、^1H NMR、^13C NMR确证。
Starting from 2-bromo-1,4-dimethoxy-3-methylnaphthalene and geraniol of bromation, the key intermediate of vitamin K2（35） was synthesized by a two-step reaction of coupling and allylic oxidation. The overall yield of the two-step reaction was 64.9%. The structure was characterized by MS,^1H NMR and ^13C NMR.
出处
《精细化工中间体》
CAS
2016年第1期43-45,共3页
Fine Chemical Intermediates
基金
黑龙江省教育厅科学技术研究项目(12541819)
关键词
维生素K2
中间体
溴代香叶醇
vitamin K2
intermediate
geraniol of bromation
