介电泳技术在生物信号检测和相分离阻变材料中的应用

Applications of dielectrophoresis in biologic signal detection and phase-separated resistance-switching materials

介电泳是操纵微纳米级粒子的强大工具,已经在生物细胞和无机微粒的分离、检测、操控方面得到了广泛的应用.本文突破对介电泳技术的传统定位,简要介绍介电泳效应的两例新的应用.首先是和新兴的纳米孔技术结合,利用介电泳的富集效应,在微纳环境下对单分子行为进行操控,解决目前纳米孔基因测序面临的通量低等难题.其次在某些相分离固体材料中,介电泳可以通过调节电子相的几何结构引起渗流,从而实现电致阻变效应.这些研究不仅扩大了介电泳技术的应用范围,且具有多学科技术交叉融合的特点,为生物检测技术的开发创新以及新型功能材料的设计提供了新的思路.

Dielectrophoresis has been used as an effective and versatile technique for trapping and sorting a wide variety of suspended materials ranging from colloidal particles to biological cells. Here two new examples about dielectrophoresis applications have been introduced beyond the traditional overview. First, combined with nanopore sensors, dielectrophoresis has been used to enrich the single molecular into nanopore, which may resolve the low throughput problem of nanopore. Next, in correlated electronic materials with various competing interactions, dielectrophoresis can reform the cluster structures of coexisting electronic phases, and lead to colossal electroresistance. These studies not only expand the applications of dielectrophoresis, but also promote the crossover between different disciplines, which can bring new ideas on the development of biological technique and the design of new functional materials.