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胎儿开放性脊柱裂和闭合性脊柱裂的超声鉴别诊断 被引量:15

The value of prenatal ultrasonic diagnosis of fetal open and closed spina bifida
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摘要 目的探讨超声诊断胎儿脊柱裂的价值及鉴别诊断开放性脊柱裂和闭合性脊柱裂的实用方法。方法回顾性分析2010年1月—2014年12月在复旦大学附属妇产科医院经过超声诊断的63例脊柱裂,包括中孕期(20.1~23.6周)超声筛查67 618例孕妇中所诊断的11例和外院转诊至我院超声诊断的52例(13.5~32.6周)。结果孕中期(20.1~23.6周)脊柱裂发生率为0.016%。开放性脊柱裂43例(占68.3%),其中合并Arnold-ChiariⅡ型异常39例,无合并Arnold-ChiariⅡ型异常的4例。闭合性脊柱裂20例(占31.7%),后颅窝池消失、双侧脑室扩张和小脑横径〈5%在开放性脊柱裂和闭合性脊柱裂中的差异有显著统计学意义(P〈0.01)。结论产前超声诊断胎儿脊柱裂具有重要临床价值。根据超声图像判断是否伴有胎儿颅脑的改变可以区分开放性脊柱裂和闭合性脊柱裂。 Objective To evaluate the value of ultrasonic diagnosis of spina bifida and identify sonographic criteria useful for differentiating open from closed spina bifida in utero. Methods We retrospectively analyzed 67 618 cases pregnant women(20.1-23.6 weeks)by midtrimester screening ultrasound diagnosis in Obstetrics and Gynecology Hospital of Fudan University,from Jan.2010 to Dec.2014.Among them11 cases of spina bifida were diagnosed by ultrasound.Another 52 cases(13.5-36.3 weeks)transferred from other hospitals were also diagnosed spina bifida by ultrasound.A total of 63 cases were enrolled. Results In this study,the rate of spina bifida was 1.6 per 10000 fetuses.Forty-three cases(68.3%)were diagnosed of open spina bifida,including 39 cases with Arnold-Chiari type Ⅱ and 4 cases without Arnold-Chiari type Ⅱ.Twenty cases(31.7%)were diagnosed of closed spina bifida.Obliteration cisterna magna,ventriculomegaly and cerebellum length5% had significant differences in open and closed spina bifida(P0.01).In closed spina bifida,associated anomalies included agenesis of corpus callosum with under cerebellar vermis,diastematomyelia,tethered cord with spinal canal lipoma,hemivertebra and spinal canal enlargement.Conclusions Ultrasound diagnosis has great value in screening spina bifida.The differentiation between open and closed defects is best shown by the sonographic demonstration of abnormal or normal cranial anatomy.
出处 《复旦学报(医学版)》 CAS CSCD 北大核心 2016年第2期195-200,共6页 Fudan University Journal of Medical Sciences
基金 上海市科学技术委员会生物医药领域科技支撑项目(14411950406)~~
关键词 脊柱裂 胎儿 畸形 超声诊断 spina bifida fetus abnormalities ultrasound diagnosis
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参考文献12

  • 1MITCHELL L, ADZICK N, MELCHIONNE J, et al. Spina bifida[J]. Lancet,2004,364(9448) : 1885 - 1895.
  • 2李胜利,顾莉莉,文华轩.胎儿开放性与闭合性脊柱裂的产前诊断及分类[J].中华医学超声杂志(电子版),2011,8(8):3-9. 被引量:49
  • 3International Society of Ultrasound in Obstetrics & Gynecology Education Committee. Sonographic examination of the fetal central nervous system:guidelines for performing the basic examination and the {etal neurosonogram[J]. Ultrasound Obstet Gynecol , 2007,29 (1):109-116.
  • 4BAHLMANN F, REINHARD I, SCHRAMM T, et al. Cranial and cerebral signs in the diagnosis of spina bifida between 18 and 22 weeks of gestation: A German mulieenter study[J]. Prenat Diagn,2015,35 (3): 228 - 235.
  • 5CAMERON M, MORAN P. Prenatal screening and diagnosis of neural tube defects[J]. Prenat Diagn, 2009, 29 (4) :402-411.
  • 6MCLONE DG, DIAS MS. The chiari Ⅱ malformation: cause and impact[J]. Childs Nerv Syst ,2003,19 (7 - 8) :540 - 550.
  • 7D'ADDARIO V, ROSSI AC, PINTO V, et al. Comparison of six sonographic signs in the prenatal diagnosis of spina bifida. [J]. J Perinat Meal,2008,36 (4) :330- 334.
  • 8GHI T,PILU G, FALCO P, et al. Prenatal diagnosis of open and closed spina bifida [J]. Ultrasound Obstet Gyneco1,2006,28 (7) :899 - 903.
  • 9钱骏,Truebenbach Jochen,Eul Thomas,Graepler Florian,Pereira Philippe,Huppert Peter,冯敢生,Claussen Claus.ACI大鼠肝细胞癌模型在介入治疗实验中的初步应用[J].中华放射学杂志,2003,37(1):16-19. 被引量:5
  • 10BABCOOK CJ, GOLDSTEIN RB, BARTH RA, et al. Prevalence of ventriculomegaly in association with myelomeningocele: correlation with gestational age and severity of posterior fossa deformity[J]. Radiology, 1994, 190 (3) :703 - 707.

二级参考文献13

  • 1Trubenbach J, Pereira PL, Graepler F, et al. Animal experiment studies on the effectiveness of permanent occlusion of the hepatic artery in transarterial chemoembolization. Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr, 2000, 172: 274-277.
  • 2Bartkowski R, Khler H, Bastian P, et al. Novel microspheres for chemo-embolization of liver metastases: experimental studies using the novikoff hepatoma rat model. Langenbecks Arch Chir, 1997, 114(Suppl): 319-323.
  • 3Verrijk R, Smolders IJ, McVie JG, et al. Polymer-coated albumin microspheres as carriers for intravascular tumor targeting of cisplatin. Cancer Chemother Pharmacol, 1991, 29: 117-121.
  • 4Verrijk R, Smolders IJH, Bosnie N, et al. Reduction of systemic exposure and toxicity of cisplatin by encapsulation in poly-lactide-co-glycolide. Cancer Res, 1992, 52: 6653-6656.
  • 5Pereira PL, Kopp A, Trüebenbach J, et al. Primre lebertumoren. Der Onkologe, 2000, 6: 301-310.
  • 6Yang R, Liu Q, Rescorla FJ, et al. Experimental liver cancer: Improved response after hepatic artery ligation and infusion of tumor necrosis factor-alpha and interferon-gamma. Surgery, 1995, 118: 768-774.
  • 7Trubenbach J, Graepler F, Pereira PL, et al. Growth characteristics and imaging properties of the morris hepatoma 3924A in ACI rats: a suitable model for transarterial chemoembolization. Cardiovasc Intervent Radiol, 2000, 23: 211-217.
  • 8P. Tortori-Donati,A. Rossi,A. Cama.Spinal dysraphism: a review of neuroradiological features with embryological correlations and proposal for a new classification[J]. Neuroradiology . 2000 (7)
  • 9Benacerraf BR,Stryker J,Frigoletto FJ.Abnormal US appearance of the cerebellum (banana sign):indirect sign of spina bifida. Radiology . 1989
  • 10李胜利,文华轩.中孕期胎儿系统超声检查切面及临床意义[J].中华医学超声杂志(电子版),2010,7(3):9-13. 被引量:100

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