载药介孔生物玻璃治疗骨髓炎的研究进展

Research progress of mesoporous bioglass applied to treat osteomyelitis

介孔生物玻璃(mesoporous bioglass,MBG)具有高度有序的孔结构、均一的孔径分布、高的孔隙率和大的比表面积,可用于药物输送,其在体外与体内两方面都呈现出更高的成骨活性,有望成为新一代的药物输送和骨修复材料。本文介绍了MBG的制备方法以及通过不同方法在MBG中加入药物,以期同时治疗感染并修复骨缺损的现有研究,但研究仍处于实验室阶段,在药物缓释制备方法上还需进一步改良。本文就载药介孔生物玻璃治疗骨髓炎的研究进展作一综述,以期为相关研究提供理论基础与实验参考。

Mesoporous bioglass （MBG） has a highly ordered porous structure, the uniformity of pore size distribution, high porosity, large specific surface area and can be used for drug delivery. It also presents a high osteogenic activity both in vitro and in vivo. It is prospected to become a new generation drug delivery and bone tissue engineering materials. In this paper, the preparation of MBG and different drug injection into MBG were introduced in order to treat infection and repair bone de-fects at the same time. But the overall study is still in the stage of laboratory. We summarized the research progress of MBG in treatment of osteomyelitis in this review so as to provide theoretical basis and experimental reference for related studies.