期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

MicroRNA在调控支气管哮喘Th1／Th2免疫应答中的研究进展 被引量：5

Advances in the regulation of microRNA in Thl/Th2 immune response of bronchial asthma
原文传递
导出
摘要 MicroRNA是一类单链非编码的小分子RNA，它通过降解目标mRNA或者抑制其翻译对基因进行转录后调控。Th1／Th2免疫应答失衡在支气管哮喘发病机制中发挥关键作用。新近研究表明，miRNA在调控Th1／Th2平衡及其相关细胞因子表达方面发挥重要作用，与支气管哮喘的发病机制密切相关，就此作一综述。 microRNA （miRNA） are short non-coding single-stranded RNA molecules. They post transcriptionally regulate gene expression. The miRNA cause degradation of target mRNA or inhibit their translation to negatively regulate gene expression. The disorders of the Thl/Th2＇s （T helpl/T help2） immune function play a crucial role in the pathogenesis of bronchial asthma. The current study shows that the importance of miRNA that govern Thl and Th2 cell fate decisions and regulate their cytokines functions in bronchial asthma. Then we made this review.
作者 孙亚敏 黄翠萍
机构地区 湖北科技学院药学院 湖北科技学院临床医学院
出处 《国际呼吸杂志》 2016年第7期533-536,共4页 International Journal of Respiration
关键词 MICRORNA 支气管哮喘 TH1/TH2 细胞因子 MicroRNA Bronchial asthma T helper type 1/type 2 cells Cytokines
分类号 R562.25 [医药卫生—呼吸系统]
  • 相关文献

参考文献22

  • 1Agache I, Akdis C, Jutel M, et al. Untangling asthma phenotypes and endotypes[J].lergy, 2012,67(7) :835-846. DOI: 10. llll/j. 1398 9995. 2012. 02832. x.
  • 2Carthew RW, Sontheimer EJ. Origins and Mechanisms of miRNAs and siRNAs[J].l, 2009, 136 (4) :642-655. DOI: 10.1016/j. cell. 2009.01.035.
  • 3Sayed D, Abdellatif M. MieroRNAs in development and disease[J].ysiol Rev, 2011,91 (3) :827-887. DOI: 10. 1152/ physrev. 00006. 2010.
  • 4Feng MJ, Shi F, Qiu C, et al. MicroRNA-181a, 146a and-146b in spleen CD4+ T lymphocytes play proinflammatory roles in a murine model of asthma[J]. Irnmunopharmacoi, 2012, 13(3) : 347-353. DOI: 10. 1016/j. intimp. 2012.05. 001.
  • 5Suojalehto H, LindstrOm I, Majuri ML, et al. Altered mieroRNA expression of nasal mucosa in long-term asthmaand allergic rhiniti[J].t Arch Allergy Immunol, 2014, 163 (3) :168 178.DOI:10.1159/000358486.
  • 6Malmhgll C, Alawieh S, Lu Y, et al. MicroRNA-155 is essential for T (H)2-mediated allergen-induced eosinophilic inflammation in the lung[J].Allergy Clin Immunol, 2014, 133(5): 1429-1438, 1438. el-7. DOI: 10. 1016/j. jaci. 2013. 11. O08.
  • 7Kuo YC, Li YS, Zhou J, et al. Human mesenchymal stem cells suppress the stretch-induced inflammatory miR-155 and eytokines in bronchial epithelial cells [J].LoS One, 2013,8 (8): e71342. DOI: 10. 1371/journal. pone. 0071342. eCollection 2013.
  • 8Trotta R, Chen L, Ciarlariello D, et al. miR-155 regulates IFN 7 production in natural killer eells[J].ood, 2012, 119 (15) :3478-3485.DOI: 10. l182/blood-2011-12-398099.
  • 9Seddiki N,Brezar V, Ruffin N, et al. Role of miR-155 in the regulation of lymphocyte immune function and disease [J].munology, 2014, 142 (1): 32-38. DOI: 10. llll/imm. 12227.
  • 10Lu TX, Munitz A, Rothenberg ME. MicroRNA-21 is ul~ regulated in allergic airway inflammation and regulates IL- 12p35 expression [J].mmunol, 2009, 182 (8) : 4994 5002. DOI : 10. 4049/jimmunol. 0803560.

同被引文献75

引证文献5

二级引证文献28

国际呼吸杂志
2016年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部