高低级别脑胶质瘤的MRS代谢产物与Ki-67表达相关性研究

Correlation of Ki-67 expression with MRS metabolism in low- and high-grade cerebral gliomas

目的：通过研究明确高低级别脑胶质瘤的磁共振波谱分析（magnetic resonance spectroscopy,MRS）代谢产物与Ki-67表达的关系。方法：选取沈阳军区总医院2013年7月至2015年7月病理证实为胶质瘤的56例患者均行Ki-67和MRS检查;分析Ki-67表达程度与瘤体Cho值、NAA值的关系。结果：35例低级别组脑胶质瘤（WHOⅠ~Ⅱ级）Ki-67的表达程度与瘤体Cho值呈正相关（r_s=0.714,P〈0.05）,与瘤体NAA值呈负相关（r_s=-0.708,P〈0.05）;21例高级别组脑胶质瘤（WHOⅢ~Ⅳ级）Ki-67的表达程度与瘤体Cho值呈正相关（r_s=0.624,P〈0.05）,Ki-67的表达程度与肿瘤实质NAA值呈负相关（r_s=-0.769,P〈0.05）。结论：高低级别脑胶质瘤MRS代谢产物与Ki-67表达相关。

objective： To investigate the relationship between magnetic resonance spectroscopy（MRS） metabolism and Ki- 67 expression in high-（HGG） and low-grade gliomas（LGG） by analyzing Ki-67 expression and HGG and LGG metabolites. Methods： We considered 56 pathologically confirmed glioma cases in our hospital. The Ki- 67 expression and the MRS metabolism parameter_s in the tumor_s were analyzed simultaneously. Results： The tumor solid value of Cho was positively correlated with the Ki-67 expression level（r_s=0.714, P〈0.05）. By contrast, the Ki-67 expression level was negatively correlated with the tumor solid value of NAA（r_s=-0.708, P〈0.05）in 35 cases of the LGG group. The tumor solid value of Cho was also positively correlated with the Ki-67 expression level（r_s=0.624, P〈0.05）. By comparison, the Ki-67 expression level was negatively correlated with the tumor solid value of NAA in the HGG group（r_s=-0.769, P〈0.05）. Conclusion： The MRS metabolism was correlated with the Ki-67 expression in high- and low-grade gliomas.