摘要
生物起搏器是治疗严重缓慢性心律失常的一个新策略,而寻找合适的起搏细胞是其首要问题。本文综述了通过转染基因、化学诱导、共培养以及特定培养基培养的方法将骨髓间充质干细胞、脂肪干细胞诱导为起搏样细胞的研究进展,分析了它们作为生物心脏起搏器种子细胞尚需解决的问题。
The biological pacemaker has become a new strategy in the treatment of severe bradycardias,in which a kind of ideal pacemaker cells is a pivotal factor.Here we reviewed the progress in the differentiation of bone-marrow mesenchymal stem cells and adipose-derived stem cells into pacemaker-like cells by means of gene transfer,chemical molecules,co-culture with other cells and specific culture media,and we also analyzed the potential issues to be solved when they are used as seeding cells of biological pacemaker.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2016年第2期378-381,387,共5页
Journal of Biomedical Engineering
基金
国家自然科学基金面上资助项目(31170934)
关键词
生物起搏器
骨髓间充质干细胞
脂肪干细胞
起搏细胞
分化
biological pacemaker
bone marrow-derived mesenchymal stem cells
adipose-derived stem cells
pacemaker cells
differentiation
