肝脏低剂量计算机断层灌注的研究进展

Research Progress of Low Radiation Dose Computed Tomography Perfusion of the Liver

肝脏计算机断层(CT)灌注成像是一种定量的无创性检测肝脏功能的影像学检查技术,主要用于肝脏肿瘤的诊断、鉴别诊断以及肝脏慢性疾病状态下的肝脏功能评价。过去,肝脏CT灌注由于辐射剂量高而限制了其在临床的应用。近年来,低剂量CT技术的开发和应用已经可以在保证图像质量的前提下大辐度降低患者的辐射剂量。本文将从X射线源、重建算法以及设备改进及扫描参数优化三个方面介绍低剂量CT灌注的研究进展。目前肝脏低剂量CT灌注的研究较少,仍有许多问题需要解决,但其在临床的应用前景将十分令人期许。

Liver computed tomography（CT）perfusion is a noninvasive imaging technology which can quantitatively investigate liver function,and it is mainly used in the diagnosis of liver tumors and assessment of liver function in the state of chronic liver diseases.The use of liver CT perfusion was limited in the past because of the high radiation dose.Now new technologies are exploited and they make it possible to reduce the radiation burden while maintaining the imaging quality.This article discusses the research progress of low radiation dose CT perfusion in 3aspects,including X-ray source,reconstruction algorithm,and improvement of CT scanners and optimization of scanning parameters.Although there are not too many studies of low radiation dose CT perfusion on liver now and many problems need to be solved,the clinical application of it will be very prospective.