5-HT信号传导通路相关基因多态性与驾驶员事故倾向性的关联

Association of 5-HT signal pathway related gene polymorphism with accident proneness in drivers

目的探讨5-羟色胺(5-HT)信号传导通路相关基因位点多态性与驾驶员事故倾向性的关联。方法研究对象来自2014年在广西工人医院体检的驾驶员,通过问卷调查将过去5年中发生≥3次责任交通事故的驾驶员纳入病例组,对照组按年龄、性别、驾驶车型、驾龄与病例组进行成组匹配;对G蛋白β3亚基(GNβ3)基因rs5443位点、脑源性神经营养因子(BDNF)基因rs6265位点和反应元件结合蛋白(CREB)基因rs6740584位点进行单核苷酸多态性(SNP)基因分型。结果 rs5443位点基因型频率分布在病例组与对照组分布有统计学差异(χ2=7.20,P=0.027),rs6265和rs6740584位点基因型频率在2组分布均无统计学差异(均P>0.05);携带rs5443位点突变基因型TT可降低事故倾向性风险,rs6265和rs6740584位点多态性在调整前后与驾驶员事故倾向性均无统计学关联。结论 GNβ3基因rs5443多态性与驾驶员的事故倾向性可能有关联。

Objective To investigate the association between 5-hydroxytryptamine（ 5-HT） signal pathway related gene polymorphism and road traffic accident（ RTA） proneness among drivers. Methods A group-matched case-control study was conducted among 300 drivers responsible for 3 or more RTA during previous 5 years and 300 age-,gender-,type of the car drived-,and driving years-matched healthy drivers without the history of being responsible for RTA during the period. Both the cases and controls were recruited at Guangxi Workers＇ Hospital,a institution for physical examination of drivers. A questionnaire survey and genotyping of rs5443 of G protein beta-3 subunit（ GNβ3） gene,rs6265 of brainderived neurotrophic factor（ BDNF）,rs6740584 of c AM P-responsive element-binding protein（ CREB） were carried out among the participants in 2014. Results There was a significant difference in the genotype distribution of GNβ3 rs5443 between the cases and the controls（ P = 0. 027） and the carries of TT genotype of GNβ3 rs5443 showed a decreased RTA proneness. However,no significant differences were observed in genotype distributions of BDNF rs6265 and CREB rs6740584 between the cases and the controls. Conclusion Single nucleotide polymorphism of GNβ3 rs5443 may be associated with RTA proneness among drivers.