期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Hippo通路在神经发育和神经系统疾病中的功能 被引量：3

The Role of Hippo Signaling in Neuronal Development and CNS Diseases
下载PDF
导出
摘要 Hippo通路是一个调控组织器官大小、细胞增殖、分化和凋亡的高度保守的信号通路.我们研究了氧化压力条件下Hippo通路在神经细胞中的作用,并发现哺乳动物STE20样的丝-苏氨酸蛋白激酶(MST1)可参与氧化应激诱导的神经细胞凋亡,其上游受非受体酪氨酸激酶c-Abl的调控.近期,我们研究发现MST1参与脑缺血引起的神经炎症,还发现Yes相关蛋白1(YAP)参与神经干细胞的自我更新.本文将介绍Hippo通路在中枢神经系统疾病和神经发育中的作用和机制研究的相关进展. Hippo signaling pathway regulates cell proliferation,differentiation and apoptosis and plays a critical role in the tissue development and homeostasis. We identified Hippo/MST1-YAP signaling is involved BMP2-mediated self-renewal of neuron progenitor cells. We also found MST1 induced neuronal cell death in oxidase stress and c-Abl,a non-receptor tyrosine kinase,function as an upstream regulator of MST1 during the process. Recently, we found MST1 play important role in ischemic stroke induced neuro-inflammation. In this review, we will briefly summarize the significant progress of Hippo signaling in the central nervous system diseases as well as neuronal development.
作者 赵思奇 王树坤 何晴 袁增强
机构地区 中国科学院生物物理研究所
出处 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2016年第4期383-388,共6页 Progress In Biochemistry and Biophysics
关键词 MST1 YAP 神经元 神经干细胞 胶质细胞 MST1 YAP neuron neural stem cells glia
分类号 Q189 [生物学—神经生物学]
  • 相关文献

参考文献37

  • 1Harvey K, Tapon N. The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network. Nature Reviews Cancer, 2007, 7(3): 182-191.
  • 2Justice R W, Zilian O, Woods D F, et ol. The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation. Genes & Development, 1995, 9(5): 534-546.
  • 3Xu T, Wang W, Zhang S, et 01. Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. Development, 1995, 121(4): 1053-1063.
  • 4Kango-Singh M, Nolo R, Tao C et al. Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila. Development 2002, 129(24): 5719-5730.
  • 5Tapon N, Harvey K F, Bell D W, et 01. Salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell, 2002, 110(4): 467-478.
  • 6Harvey K F, Pfleger C M, Hariharan I K. The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell, 2003, 114(4): 457-467.
  • 7Jia J, Zhang W, Wang B, et el. The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. Genes & Development, 2003, 17(20): 2514-2519.
  • 8Udan R S, Kango-Singh M, Nolo R, et 01. Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. Nature Cell Biology 2003, 5(10): 914-920.
  • 9Wu S, Huang J, Dong J, et ol. Hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell, 2003, 114(4): 445-456.
  • 10Huang J, Wu S, Barrera J, et al. The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. CelL, 2005, 122(3): 421 434.

同被引文献34

引证文献3

二级引证文献5

生物化学与生物物理进展
2016年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部