鼻窦炎合剂冲洗对鼻内镜术后鼻黏膜细胞的影响

Effect of Sinusitis Mixture on Mucosa Cells after Functional Endoscopic Sinus Surgery

目的探讨鼻窦炎合剂在慢性鼻窦炎鼻内镜术后的应用,从而提高慢性鼻窦炎、鼻息肉的临床疗效。方法将慢性鼻窦炎患者50例,根据术后分别应用鼻窦炎合剂或复方氯化钠注射液行术腔冲洗分为试验组及对照组(各25例),两组术前和术后4、12、24周,取上颌窦自然开口前方约0.1cm处黏膜组织,观察黏膜纤毛细胞、杯状细胞、黏膜间质、炎症细胞和黏液腺体的改变,计数上皮层的杯状细胞及纤毛细胞数及比值。结果两组治疗后术腔清洁时间、术腔上皮化时间及术后鼻杯状细胞与纤毛细胞数目及比值比较,差异均有统计学意义(t分别为-2.324、-2.015、-2.145,P<0.05)。结论鼻窦炎合剂能有效地促进和加速功能性鼻内镜术后术腔清洁时间及鼻黏膜上皮化,明显促进窦口鼻道复合体黏膜纤毛结构和功能恢复。

Objective To explore the application of sinusitis mixture（SM）in endoscopic sinus surgery,thereby improving clinical curative rate of chronic sinusitis and nasal polyps.Methods A total of 50 chronic sinusitis patients were equally assigned to the experimental group（nasal douching by SM）and the control group（nasal douching by Compound Sodium Chloride Injection）.Mucosa tissue 0.1 cm before natural opening was collected before surgery,at week4,12,and 24 after surgery.Changes of mucosa cilia cells,goblet cells,stroma of mucosal membrane,inflammatory cells,and mucous gland were observed.The numbers of goblet cells in the upper epithelia and ciliated cells,as well as their ratios were calculated.Results There was statistical difference in cavity cleaning time,cavity mucosal epithelization time,numbers of goblet cells in the upper epithelia and ciliated cells,as well as their ratio between the two groups（t=-2.342,-2.015,-2.145,respectively;P〈0.05）.Conclusion SM could effectively promote and accelerate cleaning and mucosal epithelization of functional endoscopic sinus surgery,and significantly promote mucosal ciliary structure and function recovery of ostium-meatus nasi complex.