联合检测D-二聚体、Hcy及hs-CRP与子痫前期并发DIC的相关性研究

Study on the correlation between joint detection of D-dimer,Hcy,hs-CRP and preeclampsia combined with DIC

目的探讨D-二聚体(D-dimer,D-D)、同型半胱氨酸(homocysteine,Hcy)和超敏-C反应蛋白(high-sensitivity CRP,hs-CRP)联合检测与子痫前期(Preeclampsia,PE)并发弥散性血管内凝血(Disseminated Intravascular Coagulation,DIC)的相关性。方法选取107例子痫前期患者(PE组),其中31例为重度子痫前期并发DIC患者(DIC组),39例为重度子痫前期患者(重度PE组),37例为轻度子痫前期患者(轻度PE组),110例正常妊娠孕妇作为对照组,分别检测D-二聚体、Hcy和hs-CRP,并用SPSS 19.0软件对结果进行分析比较。结果 PE组与对照组比较、DIC组与重度PE组和轻度PE组相比较、重度PE组与轻度PE组比较,D-二聚体、Hcy和hs-CRP差异均有统计学意义(P<0.01)。PE组、DIC组D-二聚体与Hcy及hs-CRP呈正相关(r=0.758、0.795,P<0.01)、(r=0.839、0.822,P<0.01),且D-二聚体、Hcy及hs-CRP浓度与PE病情轻重呈正相关(r=0.481、0.731、0.548,P<0.01)。结论 D-二聚体、Hcy及hs-CRP升高与子痫前期患者血管内皮损伤存在密切的关系,联合检测对了解子痫前期病情发展、预后判断及预防子痫前期并发DIC具有重要的临床指导意义。

Objective To explore the correlation between joint detection of D- dimer（ D- D）,homocysteine（ Hcy）,high- sensitive C-reactive protein（ hs-CRP） and preeclampsia combined with disseminated intravascular coagulation（ DIC）. Methods A total of 107 preeclampsia patients were selected as preeclampsia group,including 31 cases with severe preeclampsia combined with DIC（ DIC group）,39 cases with severe preeclampsia（ severe preeclampsia group）,and 37 cases with mild preeclampsia（ mild preeclampsia group）; 110 normal pregnant women were selected as control group. The levels of D-D,Hcy,and hs-CRP were detected,then the data was analyzed by SPSS19. 0 software. Results There were statistically significant differences in the levels of D-D,Hcy,and hs-CRP between preeclampsia group and control group（ P0. 01）; there were statistically significant differences in the levels of D-D,Hcy,and hs-CRP between DIC group and severe preeclampsia group,mild preeclampsia group（ P0. 01）; there were statistically significant differences in the levels of D-D,Hcy,and hs-CRP between severe preeclampsia group and mild preeclampsia group（ P0. 01）. In preeclampsia group and DIC group,D-D was positively correlated with Hcy and hs-CRP（ r = 0. 758,0. 795,P0. 01; r = 0. 839,0. 822,P0. 01）; the levels of D-D,Hcy,and hsCRP were positively correlated with severity of preeclampsia（ r = 0. 481,0. 731,0. 548,P0. 01）. Conclusion The high levels of D-D,Hcy,and hs-CRP are closely correlated with vascular endothelial injury of preeclampsia patients,joint detection has important clinical guiding significance in understanding development of preeclampsia,prognosis predication,and prevention of preeclampsia combined with DIC.