强化光疗治疗新生儿高胆红素血症的临床研究

Clinical study of high-intensity phototherapy in treatment of neonatal hyperbilirubinemia

目的探讨强化光疗治疗新生儿高胆红素血症的疗效。方法将该院2013年3月-2015年7月收治入院的332例新生儿高胆红素血症患儿随机分成普通光疗组和强化光疗组,比较2组患儿治疗前、治疗后4、24 h血清、皮肤胆红素变化及再次光疗率。结果普通光疗组与强化光疗组患儿治疗前血清及皮肤胆红素组间比较无统计学差异;随光疗时间的延长,血清及皮肤胆红素含量降低,其中强化光疗疗效明显优于普通光疗,24 h后血清胆红素水平和再次光疗率显著低于普通光疗组(P<0.01)。结论强化光疗通过快速有效地降低新生儿高胆红素血症胆红素水平,显著降低再次光疗率,提高疗效。

Objective To explore the curative effect of high-intensity phototheray in treatment of neonatal hyperbilirubinemia. Methods A total of 332 neonates with hyperbilirubinemia were selected from the hospital from March 2013 to July 2015 and randomly divided into conventional phototherapy group and high-intensive phototherapy group. The changes of serum and skin bilirubin levels and retreatment rates between before treatment and after 4 and 24 hours of treatment in the two groups were compared. Results Before treatment,there was no statistically significant difference in serum and skin bilirubin levels between the two groups; with the extension of phototherapy time,serum and skin bilirubin levels decreased,the curative effect in high-intensive phototherapy group was significantly better than that in conventional phototherapy group,serum bilirubin level after 24 hours of treatment and retreatment rate were significantly lower than those in conventional phototherapy group（ P0. 01）. Conclusion High-intensive phototherapy can significantly reduce retreatment rate and improve curative effect by rapidly and effectively reducing bilirubin levels of neonates with hyperbilirubinemia.