青岛成人抑郁症和2型糖尿病患病率双向关联研究

Bi-direction association on the increased prevalence of depression and type 2 diabetes among adults in Qingdao

目的 评估青岛成人抑郁和2型糖尿病的患病率以及相关危险因素,为社区开展早期慢性病危险因素预防提供科学依据。方法 研究对象来自青岛市2006年建立的横断面研究数据,通过分层随机抽样抽取6100名35～74岁常住居民（居住时间≥5年）。用Zung自评量表进行抑郁的筛检,标准2h糖耐量试验诊断糖尿病。结果2974名调查者纳入本研究,抑郁和2型糖尿病的患病率分别为10.1%和16.4%。多因素校正Logistic回归分析中,糖尿病增加抑郁患病风险,农村居民、高密度脂蛋白降低抑郁的风险（均有P〈0.05）;年龄、抑郁、体质指数、甘油三酯、高血压、糖尿病家族史、未婚与2型糖尿病患病率增长均呈正相关（均有P〈0.05）;空腹血糖与抑郁（χ2=12.32,OR=1.366,95%CI：1.151～1.622）、2h血糖与抑郁（χ2=11.35,OR=1.212,95%CI：1.081～1.358）皆存在剂量-反应关系。结论 抑郁和2型糖尿病互为两者患病率增加的独立危险因素。早期开展社区心理干预能够预防抑郁和糖尿病的发生。

Objective To evaluate the prevalence of depression and type 2 diabetes and related risk factors among adults in Qingdao, to provide evidence on early psychological intervention on communities and prevention of chronic disease risk factors. Methods A population-based cross-sectional study was conducted in Qingdao, China in 2006. A stratified random cluster sampling procedure was employed to recruit 6 100 participants aged 35-74 years living in Qingdao for at least 5 years. The Zung self-assessment score was employed to assess depression, and diabetes classification were applied using a standard oral glucose tolerance test. Results A total of 2 974 study subjects was included in the data analysis, with preva- lenees of depression and type 2 diabetes of 10. 1% and 16. 4%, respectively. Type 2 diabetes were related to depression, ru- ral residents and high density lipoprotein-cholesterol were reversely associated with depression （ all P 〈 0. 05 ）. Age, depres- sion, BMI, serum triglycerides, hypertension, family history of diabetes and unmarried status were significantly associated with increased prevalence of type 2 diabetes in a muhivariable logistic regression model（ all P 〈 0. 05 ）. There was a dose-re- sponse relationship between fasting, 2 h plasma glucose and depression. The corresponding figures were 2 = 12.32, OR = 1.366 （95% CI：1. 151-1.622） andx2 =11.35,OR=1.212 （95% CI：1.081-1.358）, respectively. Conclusions Type2 diabetes and depression is an independent risk factor for depression and type 2 diabetes prevalence in Chinese community, re- spectively. Early identification and lifestyle intervention may prevent individuals from depression and diabetes.