左西孟坦治疗顽固性心力衰竭的疗效

Therapeutic effect of levosimendan on refractory heart failure

目的：探讨左西孟坦治疗顽固性心力衰竭的临床疗效。方法：2010年9月-2014年9月来我院心内科诊断为顽固性心力衰竭的60例患者采用随机数字法被均分为常规治疗组和左西孟旦组（在常规治疗组基础上加用左西孟旦）。比较两组治疗前后的左室射血分数（LVEF）和血浆脑钠肽（BNP）水平,治疗结束60d后的6min步行距离以及治疗总有效率。结果：左西孟旦组总有效率（90.0%比76.7%）显著高于常规治疗组（P=0.03）。与常规治疗组比较,左西孟旦组治疗后LVEF[（41.53±3.42）%比（48.84±3.57）%]显著升高,6min步行距离[（371.0±69.5）m比（467.2±87.3）m]显著延长,血浆BNP[（453±39）pg/ml比（199±27）pg/ml]水平显著降低,P均〈0.05。结论：左西孟坦治疗顽固性心力衰竭疗效显著,无严重不良反应发生,值得推广。

Objective：To explore therapeutic effect of levosimendan on refractory heart failure（RHF）.Methods：A total of60 patients,who were diagnosed as RHF in our department of cardiology from Sep 2010 to Sep 2014,were selected.According to random number table,they were randomly and equally divided into routine treatment group and levosimendan group（received levosimendan based on routine treatment group）.Left ventricular ejection fraction（LVEF）,plasma level of brain natriuretic peptide（BNP）before and after treatment,6min walking distance（6MWD）on 60 dafter treatment and total effective rate were compared between two groups.Results：Total effective rate of levosimendan group was significantly higher than that of routine treatment group（90.0% vs.76.7%,P=0.03）.Compared with routine treatment group after treatment,there were significant rise in LVEF [（41.53±3.42）%vs.（48.84±3.57）%]and 6MWD [（371.0±69.5）m vs.（467.2±87.3）m],and significant reduction in plasma BNP level[（453±39）pg/ml vs.（199±27）pg/ml]in levosimendan group,P〈0.05 all.Conclusion：Levosimendan possesses significant therapeutic effect on refractory heart failure without severe adverse reaction,which is worth extending.