冠心病不同合并症患者中β凝血球蛋白的定量分析

Quantitative analysis of β thromboglobulin level in patients with coronary heart disease complicated different complications

目的:比较血清β凝血球蛋白水平在冠心病不同合并症患者间的差异。方法:按照合并疾病,398例不稳定型心绞痛(UAP)患者被分为单纯UAP组(UAP对照组,82例),高血压组(89例),糖尿病组(133例)和脑梗死组(94例)。分别检测比较4组患者发病6h时和出院前的血清β凝血球蛋白水平。随访4组半年内发生心肌梗死的情况。结果:心绞痛发作6h时,脑梗死组,糖尿病组,高血压组,UAP对照组的血清β凝血球蛋白水平[依次为(61.13±3.32)ng/ml,(59.77±3.15)ng/ml,(52.12±3.27)ng/ml,(48.55±3.14)ng/ml],以脑梗死组最高,各组间两两比较,P均<0.01,与发作6h时比较,出院前4组的血清β凝血球蛋白水平均显著降低(P均<0.01),其水平排列次序及组间差异显著性未变。4组半年内脑梗死组,糖尿病组,高血压组,UAP对照组心肌梗死发生率分别为11.7%,6.0%,3.4%,2.4%,脑梗死组的显著高于UAP对照组,P=0.04,其他组间无显著差异,P>0.05。结论:β凝血球蛋白水平在冠心病不稳定心绞痛发作时要显著高于缓解期,且于合并脑梗死者中升高最明显,半年内合并有脑梗死患者发生心肌梗死的比例也最多。

Objective：To compare serum level ofβthromboglobulin in patients with coronary heart disease（CHD）complicated different complications.Methods：According to their complications,a total of 398 patients with unstable angina pectoris（UAP）were divided into pure UAP group（UAP control group,n=82）,hypertension group（n=89）,diabetes mellitus（DM）group（n=133）and brain infarction group（n=94）.Serum level ofβthromboglobulin were measured and compared among four groups 6hafter onset and before discharge.Incidence of myocardial infarction within six months were followed up in four groups.Results：On 6hafter onset,the serum level ofβthromboglobulin of brain infarction group,DM group,hypertension group,UAP control group was（61.13±3.32）ng/ml,（59.77±3.15）ng/ml,（52.12±3.27）ng/m,（48.55±3.14）ng/ml respectively,in which the level of brain infarction group was the highest,the difference between any two groups were significant（P〈0.01all）;Compared with 6hafter onset,there were significant reductions in serum levels ofβthromboglobulin of four groups before discharge P〈0.01 all,their ordering and difference significant degree were no change.The incidence of myocardial infarction（MI）in brain infarction group,DM group,hypertension group,UAP control group was 11.7%,6.0%,3.4%,2.4% respectively,the MI incidence of brain infarction group was significant more than that of UAP control group,the differences among other groups was no significant,P〉0.05.Conclusion：β-thromboglobulin level during UAP onset is significant higher than that of remission period,and it rises most significantly in brain infarction group,and in this group the percentage of myocardial infarction occurred within six months is highest