菊粉对小鼠的免疫调节作用

Effect of Inulin on Modulating Immune Function in Mice

为探讨菊粉对小鼠的免疫调节作用,本实验以200、400、600 mg/kg的剂量对雌性BALB/c小鼠进行灌胃,每天1次,连续15 d。通过对小鼠免疫功能的测定评价不同剂量菊粉的免疫调节作用。结果显示,各剂量的菊粉灌胃组小鼠各项免疫指标均高于对照组。其中,中、高剂量组小鼠的免疫器官指数、腹腔巨噬细胞吞噬能力、血清溶血素水平、脾淋巴细胞增殖水平和γ干扰素(interferon-γ,IFN-γ)分泌水平显著(P<0.05)或极显著(P<0.01)高于对照组。以上研究结果表明,菊粉对小鼠具有较好的免疫增强作用。

To explore the effect of inulin on immune modulation in mice, 100 BALB/c female mice were allocated to control group, low-dose inulin group, mid-dose inulin group and high-dose inulin group, respectively. Then, the mice in three inulin groups were orally administered with inulin at doses of 200, 400 and 600 mg/（kg·d） body weight, respectively. After 15 days of consecutive administration, immune function indexes in these mice were detected. The results showed that inulin at both mid and high doses could significantly enhance immune organ indexes, phagocytotic capacity of peritoneal macrophages, the level of serum hemolysin, lymphocyte proliferation（SI value） and the level of interferon-γ（IFN-γ）（P〈0.05） or（P〈0.01）, indicating that inulin improves immune function in mice to some degree.