摘要
目的优化芪白平肺颗粒中人参和黄芪的提取工艺。方法在单因素试验的基础上,采用Box-Behnken响应面法,以乙醇体积分数、药液比、提取时间为自变量,并通过信息熵法对人参皂苷Rg_1+Re、人参皂苷Rb_1、黄芪甲苷的含有量及干膏率进行客观加权。然后,以综合指标为因变量,优化实验结果。结果最佳提取条件为8倍量70%乙醇,提取2次,每次2 h。结论 Box-Behnken响应面与信息熵的结合可用于优化芪白平肺颗粒的提取工艺。
AIM To optimize the exctraction processes of Panax ginseng and Astragalus membranaceus in Qibai Pingfei Granules. METHODS Based on single factor experiment,Box-Behnken response surface method was used with ethanol concentration,solvent ratio and extraction time as independent variables. The contents of ginsenoside Rg1＋ Re,ginsenosides Rb1 and astragaloside A,together with the ratio of dry extraction were objectively weighted by information entropy. Then the test result was optimized with comprehensive index as dependent variable. RESULTS The optimal extraction conditions were 8- fold 70% ethanol and extracting twice（ two hours each time）. CONCLUSION The combination of Box-Behnken response surface and information entropy can be used for optimizing the extraction process of Qibai Pingfei Granules.
出处
《中成药》
CAS
CSCD
北大核心
2016年第4期795-800,共6页
Chinese Traditional Patent Medicine
关键词
芪白平肺颗粒
人参
黄芪
提取工艺
Box-Behnken响应面
信息熵
Qibai Pingfei Granules
Panax ginseng
Astragalus membranaceus
extraction process
Box-Behnken response surface
information entropy
