摘要
目的：探讨在控制性超促排卵中克罗米芬（CC）联合高孕激素促排卵方案抑制早发LH峰的临床效果。方法：回顾性分析126名行体外受精／卵胞质内单精子显微注射（IVF／ICSI）取卵周期的患者，分为CC联合高孕激素促排卵组（试验组，n=63）和短方案治疗组（对照组，n=63）。观察过早LH峰发生率、促排卵中Gn用量和用药天数、获卵数、成熟卵数、内分泌及胚胎试验室结果。结果：试验组获卵数、成熟卵数、有效胚胎数、生化妊娠率、临床妊娠率、胚胎种植率与对照组比较均无统计学差异（P〈0．05）。所有对象在促排卵过程中未监测到早发LH峰，试验组月经第9-10日和诱发排卵日LH水平与基础值问无统计学差异（P〈0．05）。试验组Gn用量和用药天数均高于对照组（P〈0．05）。结论：CC联合高孕激素促排卵方案可以有效抑制早发LH峰，促排卵过程中LH水平平稳，且可以获得有发育潜能的胚胎。
Objective： To explore whether progestin-primed ovarian stimulation （PPOS） in combination with clomiphene citrate （CC） can be used clinically to prevent LH surges in controlled ovarian hyperstimu- lation （COH） for in vitro fertilization/intrcytoplasmic sperm injection （IVF/ICSI） cycle. Methods： A retrospective study was performed in 136 patients with normal ovarian reserve. They were divided into two groups according to the protocol used： group A with human menopausal gonadotropin （hMG） ＋medroxyprogesterone 17-acetate （MPA）＋CC （n=63）; group B with the short protocol （n=63）. The incidence of premature LH surge, dosage and durations of hMG administered, the number of oocytes retrieved, the number of mature oocytes, the number of fertilization and cleavage, hormone profiles and pregnancy outcomes from FETs were compared between the two groups. Results： The number of oocytes retrieved, the number of mature oocytes, the number of fertilization and cleavage in group A were similar to those in group B. No premature LH surges were detected in both groups. In group A, LH levels on menstruation day 9-10 and on the trigger day during the stimulation were not significantly different from the basic level. The dosage and the duration ofhMG administered were higher in group A than in group B. Conclusion： PPOS in combination with CC can effectively prevent premature LH surge, and the LH levels change smoothly and developmental potential embryos can be obtained during ovarian stimulation.
出处
《生殖与避孕》
CAS
CSCD
北大核心
2016年第4期263-269,共7页
Reproduction and Contraception
