多囊卵巢综合征患者的辅助生殖治疗结局

Assisted reproductive technology outcome in women with polycystic ovary syndrome(PCOS)

多囊卵巢综合征（PCOS）是育龄期妇女常见的内分泌紊乱性疾病，发病率达6％～10％。由于稀发排卵或无排卵，常常伴发不孕的问题。近年来，辅助生殖技术（ART）越来越多地应用于此类患者。研究表明不同类型的PCOS患者，如肥胖、高促黄体生成激素（LH）、高雄激素及胰岛素抵抗（IR），其ART助孕结局均较非PCOS患者差，虽然发生机制各有特点，但不同的病理生理异常相互作用，最终多反映为卵子质量下降，表现为PCOS患者ART治疗的临床妊娠率低、早期自然流产率高。本文就不同类型的PCOS患者的辅助生殖治疗结局以及影响其结局的因素进行论述，并探讨能够改善PCOS患者辅助生殖治疗结局的措施。

Polycystic ovary syndrome （PCOS） is the most common female endocrine disorder, affecting 6%-10% of women of childbearing age. Due to the dilute ovulation or anovulation, PCOS often associated with infertility problems. In recent years, assisted reproductive technology （ART） is increasingly used in such patients. Studies have shown that different types of PCOS patients, such as obesity, high uteinizing hormone （LH）, hyperandrogenism and insulin resistance （IR） in patients with PCOS. The ART outcomes of assisted reproduction were poorer than those in non PCOS patients. Although the mechanisms are variant, different pathophysiological abnormal interactions, which ultimately performance the decline of oocytes quality, the low clinical pregnancy rate, the high rate of early spontaneous abortion of PCOS patients treated with ART. This article will make a review about the ART outcomes of those types of PCOS and explore the way to improve the poor pregnancy rate.