维持性血液透析患者血清IL-35与心脑血管疾病的关系

Relationship between serum interleukin-35 in patients with maintenance hemodialysis and cardiovascular and cerebrovascular diseases

目的探讨维持性血液透析(MHD)患者血清白细胞介素-35(IL-35)与心脑血管疾病的关系。方法选取稳定的MHD患者72例,体检健康人30例为对照组。酶联免疫吸附法测定血清IL-35。Spearman相关分析IL-35与其它指标的相关性。结果 MHD患者IL-35水平显著低于健康对照组。心脑血管疾病患者IL-35水平明显低于无心脑血管疾病者。IL-35与左室射血分数呈正相关,与高敏C反应蛋白、氨基末端脑钠肽前体、颈动脉内膜中层厚度呈负相关。结论 MHD患者血清IL-35水平与心脑血管疾病相关,血清IL-35可能成为MHD患者心脑血管疾病新的标志物。

Objective To investigate the relationship between serum level of interleukin-35 in patients with maintenance hemodialysis（MHD）and cardiovascular and cerebrovascular diseases.Methods 72 MHD patients before undergoing hemodialysis and 30 healthy controls were selected.Serum interleukin-35 was measured by enzyme-linked immunosorbant assay（ELISA）.Spearman correlation was used to assess the relationship between serum interleukin-35 and other parameters.Results Serum interleukin-35 was significantly lower in MHD patients compared with control group;patients with cardiovascular and cerebrovascular diseases had lower serum interleukin-35 levels than those without cardiovascular and cerebrovascular diseases.MHD patients serum interleukin-35 showed positive correlation with left ventricular ejection fraction and negative correlation with high sensitive C reactive protein,amino-terminal pro-brain natriuretic peptide and carotid artery intima-media thickness.Conclusions Serum interleukin-35 level of MHD patients was associated with cardiovascular and cerebrovascular diseases;interleukin-35 might be a novel biomarker of cardiovascular and cerebrovascular diseases.