期刊文献+

急性期脑出血中组织因子途径抑制物、组织因子、纤维蛋白原、D-二聚体、超敏C反应蛋白的浓度及凝血因子Ⅶ所致的变化 被引量:8

Concentrations of tissue factor pathway inhibitor-1,tissue factor,fibrinogen,D-dimer,hypersensitive C-reactive protein,and differences caused by coagulation factor Ⅶ in acute stage of intracranial hemorrhage
下载PDF
导出
摘要 目的:分析脑出血(ICH)患者组织因子途径抑制物(TFPI-1)、组织因子(TF)、纤维蛋白原(FIB)、D-二聚体、超敏C反应蛋白(hs-CRP)及凝血因子VII(FVII:C)的变化,为早期诊断ICH提供更多的实验依据。方法:随机抽取53例ICH患者及50例体检健康者,分别作为ICH组和正常对照组。采用双抗夹心酶联免疫吸附法测定两组血清中的TFPI-1、TF、FIB、D-二聚体、hs-CRP浓度;采用一期凝固法检测FVII:C(%);统计分析ICH组与正常对照组间的差异及三者(FIB、D-二聚体、hs-CRP)单检和联检对ICH的诊断效能。结果:ICH组的TFPI-1、TF、FIB、D-二聚体、hs-CRP浓度及FVII:C均高于对照组,差异有统计学意义(P〈0.01)。血清FIB、D-二聚体及hs-CRP诊断ICH的受试者工作特征(ROC)曲线下面积分别为0.85(95%CI:0.720~0.980)、0.87(95%CI:0.731~0.970)及0.76(95%CI:0.590~0.930),三者联合检测诊断ICH的ROC曲线下面积为0.89(95%CI:0.760~0.980)。FIB、D-二聚体、hs-CRP三者联合检测的诊断灵敏度和特异度(89.5%、90.0%)较三者单检高(94.7%、75.0%)、(84.2%、90.0%)、(73.7%、89.1%)。结论:TFPI-1、TF、FIB、D-二聚体、hs-CRP水平及FVII:C与ICH的发生、发展有关;FIB、D-二聚体、hs-CRP三者联合检测可以提高诊断灵敏度和特异度。 Objective To provide more laboratory evidence for early diagnosis of intracranial hemorrhage(ICH) by analyzing the concentrations of tissue factor pathway inhibitor-1(TFPI-1), tissue factor(TF), fibrinogen(FIB), D-dimer, hypersensitive Creactive protein(hs-CRP), and differences caused by coagulation factor VII(FVII:C). Methods Totally, 53 ICH patients and 50 healthy persons were randomly selected and respectively taken as ICH group and normal control group. The concentrations of serum TFPI-1, TF, FIB, D-Dimer, hs-CRP in the two groups were detected by double-antibody sandwich enzyme-linked immuno sorbent assay; the activity of plasma F VII:C was detected by a one-stage clotting assay; the differences between the two groups,and the diagnosis efficiencies of single detection(FIB, D-Dimer, hs-CRP) and combined detection were statistically analyzed.Results The concentrations of TFPI-1, TF, FIB, D-Dimer, hs-CRP and FVII:C in ICH group were significantly higher than those in normal control group, with statistically significances(P〈0.01). The area under the receiver operating characteristic(ROC)curve of serum FIB, D-Dimer and hs-CRP for the diagnosis of ICH were respectively 0.85(95% CI: 0.720-0.980), 0.87(95%CI: 0.731-0.970) and 0.76(95% CI: 0.590-0.930). The area under the ROC curve of combined detections for the diagnosis of ICH was 0.89(95% CI: 0.760-0.980). The sensitivity and specificity of detection combined FIB, D-Dimer and hs-CRP were respectively 89.5%, 90.0%, higher than those of three single detections which were respectively(94.7%, 75.0%),(84.2%, 84.2%),(73.7%, 89.1%). Conclusion The concentrations of TFPI-1, TF, FIB, D-Dimer, hs-CRP and FVII:C are associated with the development of ICH. And the detection combined FIB, D-Dimer and hs-CRP improves the sensitivity and specificity.
出处 《中国医学物理学杂志》 CSCD 2016年第4期399-402,共4页 Chinese Journal of Medical Physics
关键词 脑出血 组织因子 凝血因子Ⅶ 纤维蛋白原 D-二聚体 超敏C反应蛋白 intracranial hemorrhage tissue factor coagulation factor Ⅶ fibrinogen D-dimer hypersensitive C-reactive protein
  • 相关文献

参考文献7

二级参考文献39

  • 1各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380. 被引量:33004
  • 2卫生部心血管病防治研究中心.中国心血管病报告2010[M].北京:中国大百科全书出版社,2011:1-13.
  • 3中华医学会心血管病学分会 中华心血管病杂志编辑委员会 中国循环杂志编辑委员会.不稳定型心绞痛诊断和治疗指南.中华心血管病杂志,2000,:409-412.
  • 4KUCH B,BOBAK M,FOBKER M,et al.Association between homocysteine and coagulation factor-α crossectional study in two population of central Europe[J].Thromb Res,2001,103(3):265-273.
  • 5DANESH J,WHINCUP P,WALKER M,et al.Fibrin D-dimer and coronary heart disease:prospective study and meta analysis[J].Circulation,2001,103(19):2323-2327.
  • 6李月春 刘国荣 莉娜 等.高同型半胱氨酸血症与脑血管病关系研究[J].中华神经科杂志,2000,33:373-373.
  • 7卫生部心血管病防治研究中心.中国心血管病报告2008-2009[M].北京:中国大百科全书出版社.2010:9.
  • 8Kassem-Moussa H, Graffagnino C. Nonocclusion and spontaneous recanalization rates in acute isehemie stroke: a review of cerebral angiography studies [J]. Arch Neural, 2002, 59(12) : 1870-1873.
  • 9Arnold M, Nedeltchev K, Brekenfeld C, et al. Outcome of acute stroke patients without visible occlusion on early artefiogra artefiography [J]. Stroke, 2004,35(5) : 1135-1138.
  • 10Slivka AP, Christoforidis GA, Bourekas EC, et al. Clinical and imaging outcomes after stroke with normal angiograms [J]. AJNR, 2005,26(2) :242-245.

共引文献621

同被引文献69

引证文献8

二级引证文献14

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部