胃癌组织Oct4和PI3K的表达和相关性

EXPRESSION AND CORRELATION OF OCT4 AND PI3K IN GASTRIC CARCINOMA

目的:探讨八聚体结合转录因子(Oct4)与磷脂酰肌醇3-激酶(PI3K)在胃癌组织中的表达和意义,并分析二者的相关性。方法:应用免疫组化S-P法检测60例胃癌组织和25例正常胃组织(距癌组织边缘10cm以上的胃组织)Oct4与PI3K蛋白的表达情况。结果:胃癌组织Oct4、PI3K的阳性表达率均明显高于癌旁正常胃组织(P<0.01);胃癌组织Oct4、PI3K的表达均与分化程度、浸润深度、淋巴结转移有关(P<0.05),与年龄和性别无关(P>0.05)。胃癌组织Oct4、PI3K的表达呈正相关关系(r=0.532,P<0.05)。结论:Oct4和PI3K可能与胃癌的发生、发展及浸润转移密切相关。

Objective： To investigate the expression and signif icance of octamer-binding transcription factor（Oct4） and phosphatidyl inositol 3–kinase（PI3K） in gastric carcinoma, and analyze the correlations between them. Methods： S-P immunohistochemical stain was used to detect the expression of Oct4 and PI3 K in 60 cases gastric carcinoma and 25 casesnormal gastric tissues. Results： The positive expression rate of Oct4 and PI3 K in gastric carcinoma was obviously higher than normal gastric tissues（P〈0.01）. In gastric carcinoma, the expression of Oct4 and PI3 K were all related to differentiated degree, inf iltration depth and lymph node metastasis（P〈0.05）; but not related to age and sex（P〈0.05）. In gastric carcinoma, the expression of Oct4 was positively correlated with PI3K（r=0.532,P〈0.05）. Conclusions： Oct4 and PI3 K may play important role in development, inf iltration and metastasis of gastric carcinoma.