双环醇联合多烯磷脂酰胆碱治疗甲亢性肝损伤的疗效观察

Efficacy Observation of Bicyclol Combined with Polyene Phosphatidylcholine in Treatment of Hyperthyroid Hepatic Dysfunction

目的探讨双环醇联合多烯磷脂酰胆碱治疗甲亢性肝脏损伤的临床疗效,以期提供可靠的保肝用药指导。方法回顾性分析2013年7月至2015年7月在我院治疗的74例甲亢性肝损伤患者的临床资料,将其按照随机数字表法分为对照组与观察组,每组各37例。所有患者均予以甲巯咪唑治疗甲亢,其中对照组在此基础上给予多烯磷脂酰胆碱保肝,观察组给予双环醇与多烯磷脂酰胆碱联合保肝治疗。对比两组患者的临床疗效和肝功能情况。结果对照组总有效率是64.86%,观察组总有效率是89.19%,差异显著(P<0.05)。观察组患者治疗后的谷丙转氨酶(ALT)、谷草转氨酶(AST)以及总胆红素(TBIL)三项指标改善程度均明显优于对照组,差异显著(P<0.05)。结论对于甲亢性肝损伤的患者,在采用双环醇与多烯磷脂酰胆碱联合保肝治疗后,能够有效降低转氨酶、胆红素指标,改善肝功能,值得临床推广应用。

Objective To study the clinical effect of bicyclol combined with polyene phosphatidylcholine in treatment of hyperthyroid hepatic dysfunction, in order to provide a reliable medication guidance in the liver protection. Methods The clinical data of 74 patients with hyperthyroid hepatic dysfunction treated in our hospital from July 2013 to July 2015 were retrospectively analyzed. According to the random number table, 74 patients were divided into control group and observation group, with 37 cases in each group. All patients were treated with methimazole, and the control group was given polyene phosphatidylcholine for liver protection, the observation group was given bicyclol combined with polyene phosphatidylcholine. The clinical efficacy and conditions of liver function were compared between two groups. Results The total effective rate of control group was 64.86%, significantly lower than 89.19% of observation group, with statistical difference （P 〈0.05）. The improvement degree of ALT, AST and TBIL in observation group was significantly better than that of control group, with statistical difference （P〈0.05）. Conclusions For patients with hyperthyroid hepatic dysfunction, bicyclol combined with polyene phosphatidylcholine can effectively reduce the levels of transaminase and bilirubin, improve the liver function, which is worthy of clinical promotion and application.