血清谷氨酸氨基转移酶与高尿酸血症的相关性分析

Analysis of correlation between serum alanine aminotransferase and hyperuricemia occurrence

目的分析血清谷氨酸氨基转移酶(ALT)升高与高尿酸血症发生的相关性。方法以69例高尿酸血症患者为观察组,以60例健康人群为对照组;分别对两组对象的血清ALT和血清尿酸(SUA)水平进行检测,对观察组患者的血清炎性因子[肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白细胞介素6(IL-6)]及脂肪因子[血清游离脂肪酸(FFA)、血清脂联素(APN)]水平进行检测。统计两组对象ALT升高的发生率,对比分析不同ALT升高程度下观察组患者血清炎性因子及脂肪因子的水平。结果观察组患者ALT升高的发生率及ALT水平均高于对照组(P<0.05)。针对观察组患者,在SUA水平上,ALT重度升高组、中度升高组、轻度升高组、未升高组依次升高(P<0.05);在血清TNF-α、CRP、IL-6及FFA水平上,ALT重度升高组、中度升高组、轻度升高组、未升高组依次升高(P<0.05),在血清APN水平上,重度升高组、中度升高组、轻度升高组、未升高组依次降低(P<0.05)。结论血清ALT升高与SUA的发生密切相关,二者指标变化趋势一致,相互影响,而影响机制可能与血清炎性因子及脂肪因子的改变有关。

Objective To analyze the relationship between serum alanine aminotransferase（ALT）and hyperuricemia occurrence.Methods Sixty-nine patients with hyperuricemia were selected as the observation group and 60 healthy people were chosen as the control group;serum levels of ALT and serum uric acid（SUA）were detected in the two groups,and the levels of serum inflammatory factors（TNF-α,CRP,IL-6）and fat factors（FFA,APN）were detected in the observation group.The occurrence rate of ALT increase in the two groups were performed statistics.The levels of serum inflammatory factors and the fat factors in the observation group were compared among different ALT increased levels.Results The occurrence rate of ALT increase and the ALT level in the observation group were higher than those in the control group（P〈0.05）.In the SUA level aiming at the patients of the observation group,the ALT severe elevated groupmoderately elevated groupmildly elevated groupnon-elevated group（P〈0.05）;in the serum TNF-α,IL-6,CRP and FFA levels,ALT severe elevated groupmoderately elevated groupmildly elevated groupnon-elevated group（P〈0.05）;in the serum APN level,severely elevated groupmoderately elevated groupmild elevated groupnon-elevated group（P〈0.05）.Conclusion The elevation of serum ALT is closely related to the occurrence of hyperuricemia,and the serum ALT level has the same varying trend with level of SUA and has interaction.The mechanism may be related to the changes of serum inflammatory factors and fat factors.