静脉注射丙种球蛋白改善小儿重症手足口病炎性因子水平的作用

Role of intravenous immunoglobulin globulin for improving inflammatory factor levels in children patients with severe hand,foot and mouth disease

目的探讨静脉注射丙种球蛋白(IVIG)改善小儿重症手足口病(HFMD)炎性因子水平的作用。方法采用回顾性分析法,选取该院收治的120例重症HFMD患儿的临床资料,将患儿分为常规治疗组(n=60)和IVIG组(n=60)。常规治疗组患儿给予一般治疗和对症治疗,IVIG组患儿在常规治疗组治疗方案的基础上增加IVIG治疗。比较治疗前后患儿炎性细胞因子变化情况。同时选取60例健康体检儿童作为对照组。结果治疗前,常规治疗组和IVIG组患儿TNF-α、CRP和IL-6水平较对照组明显升高,差异有统计学意义(P<0.05);IVIG组与常规治疗组TNF-α、CRP和IL-6水平差异无统计学意义(P>0.05)。治疗后,IVIG组较常规治疗组TNF-α、CRP和IL-6水平有明显下降(P<0.05)。结论对于重症HFMD患儿静脉注射IVIG能够有效减少TNF-α、IL-6等炎性因子的生成,促进患儿康复。

Objective To investigate the role of intravenous immunoglobulin（IVIG）for improving the inflammatory factor levels in children patients with severe hand,foot and mouth disease（HFMD）.Methods The retrospective analysis was adopted.The clinical data of 120 children patients with severe HFMD in our hospital were collected and the patients were divided into the conventional treatment group and IVIG group,60 cases in each group.The conventional treatment group was given the general treatment and symptomatic treatment,while on this basis the IVIG group was added with IVIG.The changes of inflammatory factor levels were compared between before and after treatment.At the same time 60 children undergoing the healthy physical examination were selected as the control group.Results The TNF-α,CRP and IL-6levels before treatment in the conventional treatment group and IVIG group were significantly increased compared with the control group,the difference was statistically significant（P〈0.05）;the TNF-α,CRP and IL-6levels had no statistically significant differences between the conventional treatment group and the IVIG group（P〈0.05）;the TNF-α,CRP and IL-6levels after treatment in the IVIG group were significantly decreased compared with the conventional treatment group（P〈0.05）.Conclusion IVIG for treating severe HFMD could effectively reduce the generation of inflammatory factors of TNF-α,IL-6,etc.and effectively promote patients to recover.