西格列汀对2型糖尿病患者血清对氧磷酶及氧化应激水平影响研究

Influence of sitagliptin on serum PON1 and oxidative stress levels in patients with T2DM

目的探讨西格列汀对2型糖尿病(T2DM)患者血清对氧磷酶及氧化应激水平的影响。方法纳入80例T2DM患者,随机分为西格列汀组(n=40)和二甲双胍组(n=40)。另选取40例非糖尿病健康人作为对照组。比较两组患者入组时和治疗后1个月血清总氧化态(TOS)、总抗氧化态(TAS)、氧化应激指数(OSI)及对氧磷酶(PON1)等指标检测。结果治疗前两组T2DM患者TAS和PON1水平明显低于对照组(P<0.05),而TOS和OSI水平明显高于对照组(P<0.05)。治疗后西格列汀组TAS和PON1水平较治疗前明显升高(P<0.05),而TOS和OSI水平较治疗前明显降低(P<0.05)。结论西格列汀可以有效减少T2DM患者慢性氧化应激损伤。

Objective To investigate the influence of sitagliptin on serum PON1 and oxidative stress level in the patients with type 2diabetes mellitus（T2DM）.Methods Eighty patients with T2 DM were enrolled in this study and divided into two groups：sitagliptin group and melbine group,40 cases in each group.Other healthy persons of non-diabetes were selected as the control group.The changes of serum levels of total anti-oxidative status（TAS）,total oxidative status（TOS）,oxidative stress index（OSI）and paraoxonase（PON1）at entering the group and at 1month of treatment were compared between the two groups.Results The levels of TAS and PON1 in two T2 DM groups were significantly lower than those in the control group（P〈0.05）,while the levels of TOS and OSI were significantly higher than those in the control group（P〈0.05）.After treatment,the levels of TAS and PON1 in the sitagliptin group were significantly increased compared with before treatment（P〈0.05）,while the levels of TOS and OSI were significantly reduced（P〈0.05）.Conclusion Sitagliptin could reduce chronic oxidative stress injury in the patients with T2 DM.