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C1q肿瘤坏死因子相关蛋白4研究进展 被引量：3

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摘要 C1q肿瘤坏死因子相关蛋白(C1q/tumor necrosis factor-related proteins,CTRPs)是一类新发现的蛋白超家族,与脂联素具有高度同源性。CTRPs组织分布广泛,生物学功能多样,参与调节物质代谢、血管壁细胞功能、血小板聚集、炎性反应等。CTRP4是该家族成员之一,其结构特殊,包含2个球状C1q结构域,缺乏胶原结构域。CTRP4对肿瘤、代谢、炎症及心血管疾病有重要调节作用。该文介绍CTRP4的结构特点、分布表达及其生物学功能。
作者 高洁 顾刚 陆林 王晓群
机构地区 上海交通大学医学院附属瑞金医院心脏科
出处 《国际心血管病杂志》 2016年第2期99-101,共3页 International Journal of Cardiovascular Disease
基金 国家自然科学基金青年项目(81400211)
关键词 C1q肿瘤坏死因子相关蛋白4 动脉粥样硬化 肿瘤
分类号 R543.5 [医药卫生—心血管疾病]
  • 相关文献

参考文献26

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  • 2Wong GW, Krawczyk SA, Kitidis-Mitrokostas C, et al.Molecular, biochemical and functional characterizations of Clq/TNF family members: adipose-tissue-selective expression patterns, regulation by PPARgamma agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions[J]. Biochem J, 2008, 416(2) : 161-177.
  • 3Peterson JM, Wei Z, Wong GW. CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with Clq/TNF family members~J~. Biochem Biophys Res Commun, 2009, 388(2): 360-365.
  • 4Wei Z, Peterson JM, Wong GW. Metabolic regulation by Clq/TNF-related protein-13 ( CTRP13 ): activation OF AMP-activated protein kinase and suppression of fatty acid- induced JNK signaling[J]. J Biol Chem, 2011, 286 (18) : 15652-15665.
  • 5Kishore U, Gaboriaud C, Waters P, et al. Clq and tumor necrosis factor superfamily: modularity and versatility[J]. Trends Immunol, 2004, 25(10): 551-561.
  • 6Peterson JM, Seldin MM, Tan SY, et al. CTRP2 overexpression improves insulin and lipid tolerance in diet induced obese mice[J]. PLoS One, 2014, 9(2): 01-09.
  • 7Peterson JM, Wei Z, Wong GW. Clq/TNF related protein-3 (CTRP3), a noveladipokine that regulates hepatic glucose output[J]. J Biol Chem, 2010, 285(51): 39691-39701.
  • 8Hofmann C, Chen N,Obermeier F, et al. Clq/TNF-related protein-3 (CTRP 3) is secreted by visceral adipose tissue and exerts antiinflammatory and antifibrotic effects in primary human colonic fibroblasts[J]. Inflamm Bowel Dis, 2011, 17 (12) : 2462-2471.
  • 9Kopp A, Bala M, Buechler C, et al. Clq/TNF-related protein-3 represents a novel and endogenous lipopolysaccharide antagonist of the adipose tissue [J 1. Endocrinology, 2010, 151(11): 5267 5278.
  • 10Kopp A, Bala M, Weigert J, et al. Effects of the new adiponectin paralogous protein CTRP-3 and of LPS on cytokine release from monocytes of patients with type 2 diabetes mellitus[J]. Cytokine, 2010, 49(1): 51 57.

二级参考文献70

  • 1Kishore U, Gaboriaud C, Waters P, et al. Clq and tumor necrosis factur superfamily : modularity and versatility [ J ]. Trends Immunol, 2(104, 25(10) : 551 -561.
  • 2SchMfler A, Buechler C. CTRP family: linking immunity to metabo- lism[ J]. Trends Endocrinol Metab, 2012.
  • 3I Schaffler A, Schohnerich J, Salzberger B. Adipose tissue as an immu- nological organ: Toll-like receptors, Clq/TNFs and CTRPs [ J]. Trends hnmunol, 2007, 28 (9) : 393 - 399.
  • 4Wong GW, Krawczyk SA, Kitidis-Mitrokostas C, et al. Molecular, biochemical and functional characterizations of C1 q/TNF family mem-bers : adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonist, cysteine-mediated oligomerizations, combinato- rial associations and metabolic functions [ J]. Biochem J, 2008, 416 (2) : 161 - 177.
  • 5Li Q, Wang L, Tan W, et al. Identification of ClqTNF-related pro- tein 4 as a potential cytokine that stimulates the STAT3 and NF-kap- paB pathways and promotes cell survival in human cancer cells [ J ]. Cancer Lett, 2011, 308(2) : 203 -214.
  • 6Wong GW, Wang J, Hug C, et al. A family of Acrp30/ adiponectin structural andfunctional paralogs[J]. Proc Natl Acad Sci, 2004, 101(28): 10302-10307.
  • 7Wong GW, Krawczyk SA, Kitidis-Mitrokostas C, et al. Molecular, biochemical and functional characterization of Clq/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonlst, cysteine-mediated oligomerizations associations and metabolic functions[J]. combinatorial Biochem J, 2008,416(2):161-177.
  • 8Jeon JH, Kim KY, Kim JH, et al. A novel adipokine CTRP1 stimulates aldosterone production [ J ]. FASEB J, 2008, 22(5) : 1502-1511.
  • 9Lasser G, Guchhait P, Ellsworth JL, et al. ClqTNF-related protein-1 (CTRP1): a vascular wall protein that inhibits collagen induced platelet aggregation by blocking VWF binding to collagen[J]. Blood, 2006, 107(2): 423-430.
  • 10Fraker TD Jr, Fihn SD, 2002 Chronic Stable Angina Writing Committee, et al. 2007 chronic angina foeused update of the ACC/AHA 2002 guidelines for the management of patients with chronic stable angina: a report of the American College of Cardiology/American Heart Association Task Force onPractice Guidelines Writing Group to develop the focused update of the 2002 guidelines for the management of patients with chronic stable angina[J]. J Am Coll Cardiol, 2007, 50(23) : 2264-2274.

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国际心血管病杂志
2016年 第2期

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