乳腺癌转移分子机制研究进展

Research Advancement on Molecular Mechanism of Breast Cancer Metastasis

肿瘤转移始终是癌症相关死亡的首要原因,为了更好应对肿瘤转移,临床肿瘤学正在向个体化治疗的方向发展。对乳腺癌转移分子机制的研究,使临床能够更加有效地利用靶向手段来预测转移发生的概率,进一步预防和治疗乳腺癌转移。过去的几十年,癌症转移领域的研究已取得显著性进展,临床和科研上的突破极大地丰富了我们对于原始肿瘤向致命性转移发展的认知。本文围绕基因调节下的乳腺癌转移、器官特异性定向转移,综述近年来乳腺癌转移的分子机制研究进展。

Neoplasm metastasis remains the main cause of cancer- related death. In order to find out better treatment for neoplasm metastasis,the clinical oncology focuses its research on individualized treatment. The study of the molecular mechanism of breast cancer metastasis helps to forecast the occurrence probability of the metastasis with targeting method more effectively to prevent and treat breast cancer metastasis. With the remarkable progress made in the research in the field of neoplasm metastasis during the past decades,the breakthrough in clinic and scientific research has broadened our horizons in the metastasis development of the primitive tumor turning into a fatal disease. This paper presents a review over the research advancement on the molecular mechanism of breast cancer metastasis in recent years,with breast cancer metastasis and directional metastasis of organ specificity under gene regulation as the study focus.